Advances in Transition-Metal Mediated Heterocyclic Synthesis

Advances in Transition-Metal Mediated Heterocyclic Synthesis
Author: Daniel Sole
Publisher: Academic Press
Total Pages: 368
Release: 2018-05-17
Genre: Science
ISBN: 0128116528

Advances in Transition-Metal Mediated Heterocyclic Synthesis provides an overview of recent catalytic reactions involving transition metals to produce heterocyclic compounds. The book is organized according to the type of transformation used to achieve the synthesis of the heterocyclic systems (mainly aza- and oxa-heterocycles). As such, it covers recent applications on the synthesis of heterocycles, also describing the details of the novel transformations in a didactic manner to motivate readers in search of new catalytic processes. The editors have included state-of-the-art strategies, including transition-metal reactions involving unsaturated systems (reactions of allenes, new gold(I)-catalyzed reactions, and Prins reaction). Chapters highlight the versatility of organopalladium chemistry dealing with carbonylative transformations, C-H activation reactions, coupling processes, and the control of the ambiphilic character of organopalladium species. Finally, the book discusses new reactions leading to heterocycles based on C-H activation processes catalyzed by other metals (Rh, Ru, Co). Written by an outstanding team of authors who are leading experts in organometallic chemistry and organic synthesis, this book is a valuable resource not only for chemists mainly focused on synthesis, but also for those interested in reaction mechanisms involving transition metals. - Helpfully organized by transformation type to stimulate the search for new synthetic processes - Completely illustrated and written by global experts - Includes thoughtfully selected strategies chosen by the editors to exemplify the state-of-the-art of the subject, including transition-metal reactions involving unsaturated systems, organopalladium chemistry, and metal-catalyzed C-H activation

Transition Metal-Catalyzed Heterocycle Synthesis via C-H Activation

Transition Metal-Catalyzed Heterocycle Synthesis via C-H Activation
Author: Xiao-Feng Wu
Publisher: John Wiley & Sons
Total Pages: 596
Release: 2016-03-07
Genre: Technology & Engineering
ISBN: 3527338888

Reflecting the tremendous growth of this hot topic in recent years, this book covers C-H activation with a focus on heterocycle synthesis. As such, the text provides general mechanistic aspects and gives a comprehensive overview of catalytic reactions in the presence of palladium, rhodium, ruthenium, copper, iron, cobalt, and iridium. The chapters are organized according to the transition metal used and sub-divided by type of heterocycle formed to enable quick access to the synthetic route needed. Chapters on carbonylative synthesis of heterocycles and the application of C-H activation methodology to the synthesis of natural products are also included. Written by an outstanding team of authors, this is a valuable reference for researchers in academia and industry working in the field of organic synthesis, catalysis, natural product synthesis, pharmaceutical chemistry, and crop protection.

Transition-Metal-Mediated Aromatic Ring Construction

Transition-Metal-Mediated Aromatic Ring Construction
Author: Ken Tanaka
Publisher: John Wiley & Sons
Total Pages: 785
Release: 2013-07-09
Genre: Science
ISBN: 111862999X

State-of-the-science methods, synthetic routes, and strategies to construct aromatic rings The development of new reactions for the synthesis of aromatic compounds is a highly active research area in organic synthesis, providing new functional organic materials, functional reagents, and biologically active compounds. Recently, significant advances in transition-metal-mediated reactions have enabled the efficient and practical construction of new aromatic rings with useful properties and applications. This book draws together and reviews all the latest discoveries and methods in transition-metal-mediated reactions, offering readers promising new routes to design and construct complex aromatic compounds. Integrating metal catalysis with aromatic compound synthesis, Transition-Metal-Mediated Aromatic Ring Construction offers a practical guide to the methods, synthetic routes, and strategies for constructing aromatic compounds. The book's five parts examine: [2+2+2], [2+2+1], and related cycloaddition reactions [4+2], [3+2], and related cycloaddition reactions Electrocyclization reactions Coupling and addition reactions Other important transformations, including methathesis reactions and skeletal rearrangement reactions Edited by Ken Tanaka, an internationally recognized expert in the field of transition-metal catalysis, the book features authors who are leading pioneers and researchers in synthetic reactions. Their contributions reflect a thorough review and analysis of the literature as well as their own firsthand laboratory experience developing new aromatic compounds. All chapters end with a summary and outlook, setting forth new avenues of research and forecasting new discoveries. There are also references at the end of each chapter, guiding readers to important original research reports and reviews. In summary, Transition-Metal-Mediated Aromatic Ring Construction offers synthetic chemists a promising new avenue for the development of important new aromatic compounds with a broad range of applications.

Chemoselective and Bioorthogonal Ligation Reactions

Chemoselective and Bioorthogonal Ligation Reactions
Author: W. Russ Algar
Publisher: John Wiley & Sons
Total Pages: 923
Release: 2017-03-17
Genre: Technology & Engineering
ISBN: 352768347X

This timely, one-stop reference is the first on an emerging and interdisciplinary topic. Covering both established and recently developed ligation chemistries, the book is divided into two didactic parts: a section that focuses on the details of bioorthogonal and chemoselective ligation reactions at the level of fundamental organic chemistry, and a section that focuses on applications, particularly in the areas of chemical biology, biomaterials, and bioanalysis, highlighting the capabilities and benefits of the ligation reactions. With chapters authored by outstanding scientists who range from trailblazers in the field to young and emerging leaders, this book on a highly interdisciplinary topic will be of great interest for biochemists, biologists, materials scientists, pharmaceutical chemists, organic chemists, and many others.

Heterocycles

Heterocycles
Author: Teresa M. V. D. Pinho e Melo
Publisher: John Wiley & Sons
Total Pages: 564
Release: 2022-06-20
Genre: Science
ISBN: 3527348867

Heterocycles A must-read handbook on heterocycle chemistry with a focus on sustainability Heterocycles feature prominently in our daily life—they are essential for pharmaceuticals, agrochemicals, and fine chemicals. More, numerous natural, bioactive products contain heterocyclic compounds. As a result, heterocyclic chemistry continues to be one of the most important areas of study in organic chemistry. Heterocycles provides an important reference on a wide range of topics relating to heterocyclic chemistry, with a heavy emphasis on sustainable methods and greener syntheses. The book describes state-of-the-art synthetic methods, such as photochemical reactions, dearomatization reactions, organocatalysis, transition metal catalysis, and biocatalysis. It also covers: Sustainable methods, like flow chemistry, mechanochemistry, and multicomponent synthesis Strategies for the synthesis of heterocyclic macrocycles and medium-sized rings Characterization of heterocyclic compounds Heterocycles is a useful reference for organic chemists, natural products chemists, catalytic chemists, and medicinal chemists in academia and industry.

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry
Author:
Publisher: Academic Press
Total Pages: 494
Release: 2020-04-24
Genre: Science
ISBN: 0128211725

Advances in Heterocyclic Chemistry is the definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. - Considered the definitive serial in the field of heterocyclic chemistry - Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists - Provides the latest comprehensive reviews written by established authorities in the field - Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds

Advances in Cross-Coupling Reactions

Advances in Cross-Coupling Reactions
Author: José Pérez Sestelo
Publisher: MDPI
Total Pages: 234
Release: 2020-12-03
Genre: Science
ISBN: 3039435671

In this Special Issue, recent advances in cross-coupling reactions are presented in the form of original research articles, reviews, and short communications. These contributions cover different topics in this area, including novel coupling reactions, reaction conditions, synthetic alternatives, metal ligands, and applications for new pharmaceutical compounds and organic materials. In particular, the reviews deal with methodologies such as the synthesis of diarylketones through palladium catalysis and the most relevant examples of Suzuki–Miyaura and Buchwald–Hartwig coupling reactions in the synthesis of bioactive compounds. The synthetic utility of cross-coupling reactions for the synthesis of medium-size rings and the utility of Stille and Suzuki coupling reactions for the synthesis of new molecular machines based on sterically hindered anthracenyl trypticenyl units are also summarized. The original research articles present the synthesis of 2-alkynylpyrrols by inverse Sonogashira coupling and the synthesis of indoles under oxidative dearomative cross-dehydrogenative conditions. The efficient combination of iridium-catalyzed C–H borylation of aryl halides with the Sonogashira coupling and a sequential iridium-catalyzed borylation of NH-free pyrroles followed by a Suzuki–Miyaura reaction are included. The synthesis of aryl propionic acids, a common structural motif in medicinal chemistry, and the synthesis of new organic dyes are also covered.

Carbon Monoxide in Organic Synthesis

Carbon Monoxide in Organic Synthesis
Author: Bartolo Gabriele
Publisher: John Wiley & Sons
Total Pages: 434
Release: 2022-01-10
Genre: Technology & Engineering
ISBN: 352734795X

Carbon Monoxide in Organic Synthesis A thoroughly up-to-date overview of carbonylation reactions in the presence of carbon monoxide In Carbon Monoxide in Organic Synthesis: Carbonylation Chemistry, expert researcher and chemist Bartolo Gabriele delivers a robust summary of the most central advances in the field of carbonylation reactions in the presence of carbon monoxide. Beginning with a brief introduction on the importance of carbon monoxide as a building block in modern organic synthesis, the author goes on to describe metal-catalyzed carbonylations utilizing iron, cobalt, nickel, copper, and manganese. Descriptions of palladium, ruthenium, and rhodium-catalyzed reactions follow, as do discussions of metal-free carbonylation processes. The book is organized by metal to make the book useful as a guide for researchers from both academia and industry whose work touches on the direct synthesis of carbonyl compounds, carboxylic acid derivatives, and heterocycles. It aims to stimulate further discoveries in this rapidly developing field. Readers will also enjoy: A thorough introduction to carbonylations promoted by first row transition metal catalysts, including cobalt-catalyzed and nickel-catalyzed carbonylations An exploration of carbonylations promoted by second row transition metal catalysts, including ruthenium-, rhodium-, palladium(0)-, and palladium (II)-catalyzed carbonylations Practical discussions of miscellaneous carbonylation reactions, including carbonylations promoted by third row transition metal catalysts and metal-free carbonylation processes Perfect for catalytic and organic chemists, Carbon Monoxide in Organic Synthesis: Carbonylation Chemistry is also an indispensable resource for chemists working with organometallics and industrial chemists seeking a summary of important processes used to synthesize value-added products.

C-H Bond Activation and Catalytic Functionalization I

C-H Bond Activation and Catalytic Functionalization I
Author: Pierre H. Dixneuf
Publisher: Springer
Total Pages: 269
Release: 2015-12-18
Genre: Science
ISBN: 3319246305

The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors. All chapters from Topics in Organometallic Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Organometallic Chemistry is abbreviated as Top Organomet Chem and cited as a journal.