Analysis of Human Genetic Linkage

by Jurg Ott

Author	: Jurg Ott
Publisher	: JHU Press
Total Pages	: 418
Release	: 1999-04-16
Genre	: Medical
ISBN	: 9780801861406

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Introduction and basic genetic principles; Genetic loci genetic polymorphisms; Aspects of statistical inference; Basics of linkage analysis; The informativeness of family data; Multipoint linkage analysis; Penetrance; Quantitative phenotypes; Numerical and computerized methods; Variability of the recombination fraction; Inconsistencies; Linkage analysis with mendelian disease loci; Nonparametric methods; Two-locus inheritance; Complex traits.

Mapping and Sequencing the Human Genome

by National Research Council

Author	: National Research Council
Publisher	: National Academies Press
Total Pages	: 128
Release	: 1988-01-01
Genre	: Science
ISBN	: 0309038405

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There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Linkage Disequilibrium and Association Mapping

by Andrew R. Collins

Author	: Andrew R. Collins
Publisher	: Humana
Total Pages	: 255
Release	: 2007-08-23
Genre	: Medical
ISBN	: 9781588296696

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As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analyses have emerged. In this book, scientists from around the world, who are leaders in this field, contribute their vast experience and expertise to produce a comprehensive and fascinating text for researchers and clinicians alike. They provide cutting-edge analysis of the most up-to-date and preeminent information available.

Evaluating Human Genetic Diversity

by National Research Council

Author	: National Research Council
Publisher	: National Academies Press
Total Pages	: 101
Release	: 1998-01-19
Genre	: Science
ISBN	: 0309184746

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This book assesses the scientific value and merit of research on human genetic differencesâ€"including a collection of DNA samples that represents the whole of human genetic diversityâ€"and the ethical, organizational, and policy issues surrounding such research. Evaluating Human Genetic Diversity discusses the potential uses of such collection, such as providing insight into human evolution and origins and serving as a springboard for important medical research. It also addresses issues of confidentiality and individual privacy for participants in genetic diversity research studies.

Genetic Mapping in Experimental Populations

by J. W. Van Ooijen

Author	: J. W. Van Ooijen
Publisher	: Cambridge University Press
Total Pages	: 171
Release	: 2013-08-08
Genre	: Mathematics
ISBN	: 1107013216

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A concise introduction to genetic linkage map construction for biological researchers, combining theory with practical exercises and problem-solving tips.

Statistical Genetics

by Benjamin Neale

Author	: Benjamin Neale
Publisher	: Garland Science
Total Pages	: 608
Release	: 2007-11-30
Genre	: Science
ISBN	: 1134129335

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Statistical Genetics is an advanced textbook focusing on conducting genome-wide linkage and association analysis in order to identify the genes responsible for complex behaviors and diseases. Starting with an introductory section on statistics and quantitative genetics, it covers both established and new methodologies, providing the genetic and statistical theory on which they are based. Each chapter is written by leading researchers, who give the reader the benefit of their experience with worked examples, study design, and sources of error. The text can be used in conjunction with an associated website (www.genemapping.org) that provides supplementary material and links to downloadable software.

Genetic Dissection of Complex Traits

by D.C. Rao

Author	: D.C. Rao
Publisher	: Academic Press
Total Pages	: 788
Release	: 2008-04-23
Genre	: Medical
ISBN	: 0080569110

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The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Five sections on the latest advances in complex traits Methods for testing with ethical, legal, and social implications Hot topics include discussions on systems biology approach to drug discovery; using comparative genomics for detecting human disease genes; computationally intensive challenges, and more

Genetics and Genomics of Eye Disease

by Xiaoyi Raymond Gao

Author	: Xiaoyi Raymond Gao
Publisher	: Academic Press
Total Pages	: 386
Release	: 2019-09-12
Genre	: Science
ISBN	: 0128167270

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Genetics and Genomics of Eye Disease: Advancing to Precision Medicine thoroughly examines the latest genomics methods for studying eye disease, including complex eye disorders associated with multiple genes. GWAS, WES, WGS, RNA-sequencing, and transcriptome analysis as employed in ocular genomics are discussed in-depth, as are genomics findings tied to early-onset glaucoma, strabismus, age-related macular degeneration, adult-onset glaucoma, diabetic retinopathy, keratoconus, and leber congenital amaurosis, among other diseases. Research and clinical specialists offer guidance on conducting preventative screenings and counseling patients, as well as the promise of machine learning, computational statistics and artificial intelligence in advancing ocular genomics research. - Offers thorough guidance on conducting genetic and genomic studies of eye disease - Examines the genetic basis of a wide range of complex eye diseases and single-gene and Mendelian disorders - Discusses the application of genetic testing and genetic risk prediction in eye disease diagnosis and patient counseling

Statistics in Human Genetics

by Pak Sham

Author	: Pak Sham
Publisher	: Wiley
Total Pages	: 0
Release	: 1997-12-08
Genre	: Science
ISBN	: 9780470689288

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Rigorous statistical analysis methods for human genetics application Statistics in Human Genetics explores the statistical analysis methods that are critical to good science. Beginning with a brief review of genes, gene structure, variation, and terminology, the book moves into analysis of segregation, genetic linkage, allelic associations, and continuity for a wide range of conditions. From the classic Hardy-Weinberg equation to advanced modeling, algorithms and more, this book provides authoritative guidance toward methods, analysis, and applications for anyone performing quantitative analysis of human genetics.