Animal Hematotoxicology

Animal Hematotoxicology
Author: G.O. Evans
Publisher: CRC Press
Total Pages: 222
Release: 2008-07-25
Genre: Medical
ISBN: 1420080105

Hematology data from in vivo toxicology studies remains one of the most predictive measures for human risk, as the same measurements made in pre-clinical toxicology studies can be made in early clinical trials. Covering the three main blood cell types - erythrocytes, leukocytes and thrombocytes, this work is designed to clarify topics fo

Animal Clinical Chemistry

Animal Clinical Chemistry
Author: G.O. Evans
Publisher: CRC Press
Total Pages: 230
Release: 1996-04-29
Genre: Medical
ISBN: 0748403507

By presenting background information on the selection and application of biochemical tests in safety assessment studies, this text seeks to provide a basis for improving the knowledge required to interpret data from toxicological studies. In addition to chapters which discuss the assessment of specific organ toxicity (such as the liver, kidney and thyroid), the book also covers pre-analytical variables, regulatory requirements and statistical approaches, and highlights some of the major differences between man and different laboratory animals. The editor and contributor are all members of the Animal Clinical Chemistry Association, a group formed to advance the science of animal clinical chemistry in safety evaluation, toxicology and veterinary science.

Human Stem Cell Toxicology

Human Stem Cell Toxicology
Author: James L Sherley
Publisher: Royal Society of Chemistry
Total Pages: 316
Release: 2016
Genre: Medical
ISBN: 178262421X

Toxicity against tissue stem cells (TSCs) is a major problem in drug development and environmental health science. Despite their essential function in all human cellular tissues, the nature of tissue stem cells is not fully understood. The small fraction of stem cells in tissues and the lack of specific biomarkers for their quantification present a formidable challenge to developing tools for their study and assays that can identify stem cell-toxic agents. Human Stem Cell Toxicology reveals TSC toxicity as a biomedical reality that is now well under siege by newly emerging ideas and technologies, despite these challenges. Chapters consider stem cell toxicity by environmental agents, pharmaceutical drug candidates, and marketed therapeutic medicines with adverse side effects. New insights to cellular, molecular, biochemical and chemical mechanisms of human tissue stem cell toxicity are brought together. Experimental and theoretical treatments are of specific topics, including approaches to monitoring TSC function, newly discovered TSC types and TSC toxicity resistance mechanisms are covered by expert authors. This book informs and champions the continued development of innovative technologies to predict the TSC toxicity of compounds before their use, whether in patients or the environment, by addressing emerging new cell-based approaches and concepts for technical innovation. This publication will be a useful reference for postgraduate students and researchers working in toxicology, pharmaceutical science, tissue cell biology and stem cell biology.

Ruminant Toxicology, An Issue of Veterinary Clinics: Food Animal Practice

Ruminant Toxicology, An Issue of Veterinary Clinics: Food Animal Practice
Author: Gary Osweiler
Publisher: Elsevier Health Sciences
Total Pages: 294
Release: 2011-07-28
Genre: Medical
ISBN: 1455709166

Guest Editor Gary Osweiler presents a comprehensive look at ruminant toxicology. Topics will include biofuels co-products tolerance and toxicology for ruminants, diagnostic toxicology for ruminants, metal/mineral poisoning and interactions, reproductive toxicants in forage and grain crops, ruminant mycotoxicoses, antidotes and therapy for ruminant toxicants, western plant hazardous to ruminants, southeastern toxic plants affecting ruminants, northeastern plants toxic to ruminants, industrial and commercial products affecting ruminants, water quality and ruminant health and productivity, ,and much more!

Animal Clinical Chemistry

Animal Clinical Chemistry
Author: G.O. Evans
Publisher: CRC Press
Total Pages: 360
Release: 2009-04-01
Genre: Medical
ISBN: 1420080121

10+ Years of Updates Since First EditionNewcomers to the animal clinical chemistry and toxicology fields quickly find that the same rules of human medicine do not always apply. Following in the footsteps of its standard-setting first edition, Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers, Second Editio

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

A Comprehensive Guide to Toxicology in Nonclinical Drug Development
Author: Ali S. Faqi
Publisher: Academic Press
Total Pages: 988
Release: 2016-11-03
Genre: Medical
ISBN: 0128036214

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. - Provides unique content that is not always covered together in one comprehensive resource, including chapters on stem cells, abuse liability, biomarkers, inhalation toxicology, biostatistics, and more - Updated with the latest international guidelines for nonclinical toxicology in both small and large molecules - Incorporates practical examples in order to illustrate day-to-day activities and the expectations associated with working in nonclinical toxicology

Comprehensive Toxicology

Comprehensive Toxicology
Author:
Publisher: Elsevier
Total Pages: 8639
Release: 2017-12-01
Genre: Science
ISBN: 0081006128

Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts