The Olifants catchment is one of 19 Catchment Management Areas in South Africa. Different water users (i.e., rural, urban, mining, subsistence and commercial irrigated agriculture, commercial forestry, industry and power generation) are present in the catchment. Rising population andincreasing water provision in rural areas, in conjunction with the development of the mining industry, the construction of new power generation plants, the implementation of environmental flows andthe need to meet international flow requirements are going to greatly exacerbate the complexity of future water resources management in what is already a water-stressed catchment. Being able to assess the ability of the catchment to satisfy potential water demands is crucial in order to plan for the future and make wise decisions. In this study, a scenario analysis approach was used in conjunction with the Water Evaluation And Planning model, in order to assess the impacts of possible water demands on the water resources of the Olifants catchment in 2025. Foreach scenario, the water resource implications were compared to a 1995 “baseline.” The model enabled analyses of unmet water demands, streamflows and water storage for each scenario. The model results show that for the different scenarios considered in this study the implementation of the Environmental Reserve (an instream requirement to guarantee the health of the riverine ecosystems) will increase the shortages for other sectors. The construction of the main water storage infrastructure proposed by the Department of Water Affairs and Forestry, in conjunction with the application of Water Conservation and Demand Management practices, can reduce the unmet demands and shortfalls to levels lower than, or similar to, those experienced in the 1995 baseline. However, in all cases these interventions will be insufficient to completely meet the demands of all the sectors. A tight control of the growth in future demands is essential, although this may be difficult in a rapidly developing country like South Africa.