Basic Biostatistics for Geneticists and Epidemiologists

Basic Biostatistics for Geneticists and Epidemiologists
Author: Robert C. Elston
Publisher: John Wiley & Sons
Total Pages: 384
Release: 2008-11-20
Genre: Medical
ISBN: 0470024917

Anyone who attempts to read genetics or epidemiology research literature needs to understand the essentials of biostatistics. This book, a revised new edition of the successful Essentials of Biostatistics has been written to provide such an understanding to those who have little or no statistical background and who need to keep abreast of new findings in this fast moving field. Unlike many other elementary books on biostatistics, the main focus of this book is to explain basic concepts needed to understand statistical procedures. This Book: Surveys basic statistical methods used in the genetics and epidemiology literature, including maximum likelihood and least squares. Introduces methods, such as permutation testing and bootstrapping, that are becoming more widely used in both genetic and epidemiological research. Is illustrated throughout with simple examples to clarify the statistical methodology. Explains Bayes’ theorem pictorially. Features exercises, with answers to alternate questions, enabling use as a course text. Written at an elementary mathematical level so that readers with high school mathematics will find the content accessible. Graduate students studying genetic epidemiology, researchers and practitioners from genetics, epidemiology, biology, medical research and statistics will find this an invaluable introduction to statistics.

Biostatistical Genetics and Genetic Epidemiology

Biostatistical Genetics and Genetic Epidemiology
Author: Robert C. Elston
Publisher: John Wiley & Sons
Total Pages: 860
Release: 2002-04-22
Genre: Medical
ISBN: 9780471486312

"Human Genetics and Genetic Epidemiology" ist der 3. Band aus der sehr erfolgreichen Reihe 'Wiley Biostatistics Reference Series', die auf Artikeln der "Encyclopedia of Biostatistics" basiert. Dieser Band gibt einen topaktuellen und umfassenden Überblick über ein Forschungsgebiet, das insbesondere im Zuge des Human-Genomprojekts eine regelrechte Explosion an Forschungsaktivitäten erlebt hat. Enthalten sind komplett aktualisierte Artikel aus der "Encyclopedia of Biostatistics" sowie über 25% neue Artikel. Mit einem komplexen System an Querverweisen, die das Auffinden der gewünschten Information erheblich erleichtern. Eine interessante Lektüre für Genetiker, Epidemiologen, Biostatistiker und Forscher in diesen Bereichen.

Statistical Methods in Genetic Epidemiology

Statistical Methods in Genetic Epidemiology
Author: Duncan C. Thomas
Publisher: Oxford University Press
Total Pages: 458
Release: 2004-01-29
Genre: Medical
ISBN: 0199748055

This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process. Although the book is oriented primarily towards graduate students in epidemiology, biostatistics and human genetics, it will also serve as a comprehensive reference work for researchers. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics will help make the book accessible to those coming from one of these fields without a background in the others. It strikes a good balance between epidemiologic study designs and statistical methods of data analysis.

The Fundamentals of Modern Statistical Genetics

The Fundamentals of Modern Statistical Genetics
Author: Nan M. Laird
Publisher: Springer Science & Business Media
Total Pages: 226
Release: 2010-12-13
Genre: Medical
ISBN: 1441973389

This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed.

Epidemiology, Biostatistics, and Preventive Medicine

Epidemiology, Biostatistics, and Preventive Medicine
Author: James F. Jekel
Publisher: Elsevier Health Sciences
Total Pages: 436
Release: 2007-01-01
Genre: Medical
ISBN: 141603496X

You'll find the latest on healthcare policy and financing, infectious diseases, chronic disease, and disease prevention technology.

Fundamentals of Genetic Epidemiology

Fundamentals of Genetic Epidemiology
Author: Muin J. Khoury
Publisher: Monographs in Epidemiology and
Total Pages: 394
Release: 1993
Genre: Medical
ISBN: 0195052889

This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease aetiology. The authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations.

Tutorials in Biostatistics, Statistical Methods in Clinical Studies

Tutorials in Biostatistics, Statistical Methods in Clinical Studies
Author: Ralph B. D'Agostino
Publisher: John Wiley & Sons
Total Pages: 466
Release: 2005-09-27
Genre: Mathematics
ISBN: 047002366X

The Tutorials in Biostatistics have become a very popular feature of the prestigious Wiley journal, Statistics in Medicine (SIM). The introductory style and practical focus make them accessible to a wide audience including medical practitioners with limited statistical knowledge. This book represents the first of two volumes presenting the best tutorials published in SIM, focusing on statistical methods in clinical studies. Topics include the design and analysis of clinical trials, epidemiology, survival analysis, and data monitoring. Each tutorial is focused on a medical problem, has been fully peer-reviewed and edited, and is authored by leading researchers in biostatistics. Many articles include an appendix on the latest developments since publication in the journal and additional references. This will appeal to statisticians working in medical research, as well as statistically-minded clinicians, biologists, epidemiologists and geneticists. It will also appeal to graduate students of biostatistics.

Basic Epidemiology

Basic Epidemiology
Author: R. Bonita
Publisher: World Health Organization
Total Pages: 227
Release: 2006
Genre: Medical
ISBN: 9241547073

Basic epidemiology provides an introduction to the core principles and methods of epidemiology, with a special emphasis on public health applications in developing countries. This edition includes chapters on the nature and uses of epidemiology; the epidemiological approach to defining and measuring the occurrence of health-related states in populations; the strengths and limitations of epidemiological study designs; and the role of epidemiology in evaluating the effectiveness and efficiency of health care. The book has a particular emphasis on modifiable environmental factors and encourages the application of epidemiology to the prevention of disease and the promotion of health, including environmental and occupational health.

Statistical Methods in Environmental Epidemiology

Statistical Methods in Environmental Epidemiology
Author: Duncan C. Thomas
Publisher: Oxford University Press, USA
Total Pages: 450
Release: 2009
Genre: Medical
ISBN: 0191552682

A systematic treatment of the statistical challenges that arise in environmental health studies and the use epidemiologic data in formulating public policy, at a level suitable for graduate students and epidemiologic researchers.