Bioimaging in Neurodegeneration

Bioimaging in Neurodegeneration
Author: Patricia A. Broderick
Publisher: Springer Science & Business Media
Total Pages: 313
Release: 2007-11-05
Genre: Medical
ISBN: 1592598889

Bioimaging is in the forefront of medicine for the diagnosis and helps to predict the progression of AD via mild cognitive treatment of neurodegenerative disease. Conventional magnetic impairment (MCI) studies. resonance imaging (MRI) uses interactive external magnetic fields Novel neuroimaging technologies, such as neuromolecular and resonant frequencies of protons from water molecules. imaging (NMI) with a series of newly developed BRODERICK ® However, newer sequences, such as magnetization-prepared rapid PROBE sensors, directly image neurotransmitters, precursors, acquisition gradient echo (MPRAGE), are able to seek higher and metabolites in vivo, in real time and within seconds, at separate levels of anatomic resolution by allowing more rapid temporal and selective waveform potentials. NMI, which uses an imaging. Magnetic resonance spectroscopy (MRS) images electrochemical basis for detection, enables the differentiation of metabolic changes, enabling underlying pathophysiologic neurodegenerative diseases in patients who present with mesial dysfunction in neurodegeneration to be deciphered. Neuro- versus neocortical temporal lobe epilepsy. In fact, NMI has some 1 chemicals visible with proton H MRS include N-acetyl aspartate remarkable similarities to MRI insofar as there is technological (NAA), creatine/phosphocreatine (Cr), and choline (Cho); NAA dependence on electron and proton transfer, respectively, and is considered to act as an in vivo marker for neuronal loss and/or further dependence is seen in both NMI and MRI on tissue neuronal dysfunction. By extending imaging to the study of composition such as lipids.

Quantitative Magnetic Resonance Imaging

Quantitative Magnetic Resonance Imaging
Author: Nicole Seiberlich
Publisher: Academic Press
Total Pages: 1094
Release: 2020-11-18
Genre: Computers
ISBN: 0128170581

Quantitative Magnetic Resonance Imaging is a 'go-to' reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: - The basic physics behind tissue property mapping - How to implement basic pulse sequences for the quantitative measurement of tissue properties - The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* - The pros and cons for different approaches to mapping perfusion - The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor - maps and more complex representations of diffusion - How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed - How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance - Fingerprinting can be used to accelerate or improve tissue property mapping schemes - How tissue property mapping is used clinically in different organs - Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds - Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements - Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges - Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches

The Neuroscience of Parkinson's Disease

The Neuroscience of Parkinson's Disease
Author: Colin R Martin
Publisher: Academic Press
Total Pages: 1548
Release: 2020-12-21
Genre: Medical
ISBN: 0128159596

The Neuroscience of Parkinson's Disease (two volume set) provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. The book also fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson's disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. - Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease - Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations - Serves as a "one-stop" source for everything you need to know about Parkinson's disease

Nanomedical Drug Delivery for Neurodegenerative Diseases

Nanomedical Drug Delivery for Neurodegenerative Diseases
Author: Awesh K. Yadav
Publisher: Academic Press
Total Pages: 284
Release: 2022-03-10
Genre: Medical
ISBN: 0323898017

Nanomedical Drug Delivery for Neurodegenerative Diseases opens the door for promising approaches and advances in the diagnosis and treatment of various neurodegenerative diseases. The contents of the book comprise all the aspects related to the design, synthesis, and application of different nanodrug delivery systems in the treatment of neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and motor neuron diseases. This book explores how nanoparticulate drug carriers can improve therapeutic efficacy by selecting a suitable design strategy. Nanomedical Drug Delivery for Neurodegenerative Diseases is a valuable resource for graduates, clinical researchers, and other scientists working to minimize the challenges to deliver the drugs and genes in a more efficient and targeted manner for the treatment of neurodegenerative diseases. - Includes design, synthesis and applications of drug delivery systems - Explores the role of nanotechnology in the diagnosis and treatment of neurodegenerative disorders - Reviews applications for the management of Parkinson's disease, Alzheimer's disease, Huntington's disease, and motor neuron diseases - Discusses extracellular vesicles and mitochondria-targeted bioactive delivery systems - Details how nanocarrier-based delivery is useful to improve efficacy and cure

Neurodegeneration Nanotechnology in Neurodegenerative Diseases

Neurodegeneration Nanotechnology in Neurodegenerative Diseases
Author: Shakeel Ahmed
Publisher: Cambridge Scholars Publishing
Total Pages: 335
Release: 2024-09-27
Genre: Medical
ISBN: 1036411729

This book stems from the urgent necessity to address neurodegenerative diseases, which are among the most severe health challenges currently confronting society. Neurodegenerative diseases have become a major threat to public health in recent years, impacting millions of people globally and creating a substantial strain on healthcare systems and society as a whole. Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis are examples of these diseases. This book offers a thorough survey of the latest developments in this rapidly growing field. This book is targeted towards a wide range of readers, including academics, researchers, medical professionals, students, policy makers, and anybody else who is interested in the convergence of neuroscience, nanotechnology, and healthcare. Irrespective of one's familiarity with the subject, this book provides motivation and insightful information to bolster our group's endeavors in combating these debilitating diseases.

Neurodegeneration in Multiple Sclerosis

Neurodegeneration in Multiple Sclerosis
Author: M. Filippi
Publisher: Springer Science & Business Media
Total Pages: 233
Release: 2008-02-01
Genre: Medical
ISBN: 8847003911

Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.

MRI: The Basics

MRI: The Basics
Author: Ray Hashman Hashemi
Publisher: Lippincott Williams & Wilkins
Total Pages: 400
Release: 2012-03-28
Genre: Medical
ISBN: 1451148712

Now in its updated Third Edition, MRI: The Basics is an easy-to-read, clinically relevant introduction to the physics behind MR imaging. The book features large-size, legible equations, state-of-the-art images, instructive diagrams, and questions and answers that are ideal for board review. The American Journal of Radiology praised the previous edition as "an excellent text for introducing the basic concepts to individuals interested in clinical MRI." This edition spans the gamut from basic physics to multi-use MR options to specific applications, and has dozens of new images. Coverage reflects the latest advances in MRI and includes completely new chapters on k-space, parallel imaging, cardiac MRI, and MR spectroscopy.

Biomedical Imaging in Experimental Neuroscience

Biomedical Imaging in Experimental Neuroscience
Author: Nick Van Bruggen
Publisher: CRC Press
Total Pages: 368
Release: 2002-12-23
Genre: Medical
ISBN: 1420042157

With the emergence of genetically manipulated laboratory mice as one of the most powerful tools for neuroscientists, imaging techniques capable of providing anatomical and functional information of small animals have become extremely important. Emphasizing data analysis and interpretation, Biomedical Imaging in Experimental Neuroscience presents a comprehensive review of the noninvasive biomedical imaging techniques available for laboratory animal research. It covers the scope and limitations of these methods and analyzes their impact on in vivo neuroscience research. The book also provides a concise theoretical description of the pertinent physics.