Biomedical Imaging and Computational Modeling in Biomechanics

by Ugo Andreaus
Biomedical Imaging and Computational Modeling in Biomechanics
Author: Ugo Andreaus
Publisher: Springer Science & Business Media
Total Pages: 208
Release: 2012-10-09
Genre: Technology & Engineering
ISBN: 940074269X
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This book collects the state-of-art and new trends in image analysis and biomechanics. It covers a wide field of scientific and cultural topics, ranging from remodeling of bone tissue under the mechanical stimulus up to optimizing the performance of sports equipment, through the patient-specific modeling in orthopedics, microtomography and its application in oral and implant research, computational modeling in the field of hip prostheses, image based model development and analysis of the human knee joint, kinematics of the hip joint, micro-scale analysis of compositional and mechanical properties of dentin, automated techniques for cervical cell image analysis, and biomedical imaging and computational modeling in cardiovascular disease. The book will be of interest to researchers, Ph.D students, and graduate students with multidisciplinary interests related to image analysis and understanding, medical imaging, biomechanics, simulation and modeling, experimental analysis

Computational Modeling in Biomechanics

by Suvranu De
Computational Modeling in Biomechanics
Author: Suvranu De
Publisher: Springer Science & Business Media
Total Pages: 580
Release: 2010-03-10
Genre: Technology & Engineering
ISBN: 9048135753
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Availability of advanced computational technology has fundamentally altered the investigative paradigm in the field of biomechanics. Armed with sophisticated computational tools, researchers are seeking answers to fundamental questions by exploring complex biomechanical phenomena at the molecular, cellular, tissue and organ levels. The computational armamentarium includes such diverse tools as the ab initio quantum mechanical and molecular dynamics methods at the atomistic scales and the finite element, boundary element, meshfree as well as immersed boundary and lattice-Boltzmann methods at the continuum scales. Multiscale methods that link various scales are also being developed. While most applications require forward analysis, e.g., finding deformations and stresses as a result of loading, others involve determination of constitutive parameters based on tissue imaging and inverse analysis. This book provides a glimpse of the diverse and important roles that modern computational technology is playing in various areas of biomechanics including biofluids and mass transfer, cardiovascular mechanics, musculoskeletal mechanics, soft tissue mechanics, and biomolecular mechanics.

Computational Biomechanics

by Masao Tanaka
Computational Biomechanics
Author: Masao Tanaka
Publisher: Springer Science & Business Media
Total Pages: 207
Release: 2012-03-22
Genre: Technology & Engineering
ISBN: 4431540733
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Rapid developments have taken place in biological/biomedical measurement and imaging technologies as well as in computer analysis and information technologies. The increase in data obtained with such technologies invites the reader into a virtual world that represents realistic biological tissue or organ structures in digital form and allows for simulation and what is called “in silico medicine.” This volume is the third in a textbook series and covers both the basics of continuum mechanics of biosolids and biofluids and the theoretical core of computational methods for continuum mechanics analyses. Several biomechanics problems are provided for better understanding of computational modeling and analysis. Topics include the mechanics of solid and fluid bodies, fundamental characteristics of biosolids and biofluids, computational methods in biomechanics analysis/simulation, practical problems in orthopedic biomechanics, dental biomechanics, ophthalmic biomechanics, cardiovascular biomechanics, hemodynamics, cell mechanics, and model-, rule-, and image-based methods in computational biomechanics analysis and simulation. The book is an excellent resource for graduate school-level engineering students and young researchers in bioengineering and biomedicine.

Computational Biomechanics

by Kozaburo Hayashi
Computational Biomechanics
Author: Kozaburo Hayashi
Publisher: Springer Science & Business Media
Total Pages: 278
Release: 2012-12-06
Genre: Medical
ISBN: 4431669515
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The combination of readily available computing power and progress in numerical techniques has made nonlinear systems - the kind that only a few years ago were ignored as too complex - open to analysis for the first time. Now realistic models of living systems incorporating the nonlinear variation and anisotropic nature of physical properties can be solved numerically on modern computers to give realistically usable results. This has opened up new and exciting possibilities for the fusing of ideas from physiology and engineering in the burgeoning new field that is biomechanics. Computational Biomechanics presents pioneering work focusing on the areas of orthopedic and circulatory mechanics, using experimental results to confirm or improve the relevant mathematical models and parameters. Together with two companion volumes, Biomechanics: Functional Adaptation and Remodeling and the Data Book on Mechanical Properties of Living Cells, Tissues, and Organs, this monograph will prove invaluable to those working in fields ranging from medical science and clinical medicine to biomedical engineering and applied mechanics.

Computational Bioengineering and Bioinformatics

by Nenad Filipovic
Computational Bioengineering and Bioinformatics
Author: Nenad Filipovic
Publisher: Springer
Total Pages: 169
Release: 2021-03-12
Genre: Technology & Engineering
ISBN: 9783030436605
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This book explores the latest and most relevant topics in the field of computational bioengineering and bioinformatics, with a particular focus on patient-specific, disease-progression modeling. It covers computational methods for cardiovascular disease prediction, with an emphasis on biomechanics, biomedical decision support systems, data mining, personalized diagnostics, bio-signal processing, protein structure prediction, biomedical image processing, analysis and visualization, and high-performance computing. It also discusses state-of-the-art tools for disease characterization, and recent advances in areas such as biomechanics, cardiovascular engineering, patient-specific modeling, population-based modeling, multiscale modeling, image processing, data mining, biomedical decision-support systems, signal processing, biomaterials and dental biomechanics, tissue and cell engineering, computational chemistry and high-performance computing. As such, it is a valuable resource for researchers, medical and bioengineering students, and medical device and software experts

Soft Tissue Biomechanical Modeling for Computer Assisted Surgery

by Yohan Payan
Soft Tissue Biomechanical Modeling for Computer Assisted Surgery
Author: Yohan Payan
Publisher: Springer Science & Business Media
Total Pages: 392
Release: 2012-04-27
Genre: Technology & Engineering
ISBN: 3642290140
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This volume focuses on the biomechanical modeling of biological tissues in the context of Computer Assisted Surgery (CAS). More specifically, deformable soft tissues are addressed since they are the subject of the most recent developments in this field. The pioneering works on this CAS topic date from the 1980's, with applications in orthopaedics and biomechanical models of bones. More recently, however, biomechanical models of soft tissues have been proposed since most of the human body is made of soft organs that can be deformed by the surgical gesture. Such models are much more complicated to handle since the tissues can be subject to large deformations (non-linear geometrical framework) as well as complex stress/strain relationships (non-linear mechanical framework). Part 1 of the volume presents biomechanical models that have been developed in a CAS context and used during surgery. This is particularly new since most of the soft tissues models already proposed concern Computer Assisted Planning, with a pre-operative use of the models. Then, the volume addresses the two key issues raised for an intra-operative use of soft tissues models, namely (Part 2) “how to estimate the in vivo mechanical behavior of the tissues?” (i.e. what are the values of the mechanical parameters that can deliver realistic patient-specific behavior?) and (Part 3) “how to build a modeling platform that provides generic real-time (or at least interactive-time) numerical simulations?”

Computational Bioengineering

by M. Cerrolaza
Computational Bioengineering
Author: M. Cerrolaza
Publisher: Imperial College Press
Total Pages: 264
Release: 2004
Genre: Science
ISBN: 9781860945403
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This book is a significant contribution to the state of the art in the field of computational bioengineering from the need for a living human database to meshless methods in biomechanics, from computational mechanobiology to the evaluation of stresses in hip prosthesis replacement, from lattice Boltzmann methods for analyzing blood flow to the analysis of fluid movement in long bones, among other interesting topics treated herein. Well-known international experts in bioengineering have contributed to the book, giving it a unique style and cutting-edge material for graduate students, academic researchers and design bioengineers, as well as those interested in getting a better understanding of such complex and fascinating human and living processes.

Computational Modeling in Tissue Engineering

by Liesbet Geris
Computational Modeling in Tissue Engineering
Author: Liesbet Geris
Publisher: Springer Science & Business Media
Total Pages: 438
Release: 2012-10-30
Genre: Technology & Engineering
ISBN: 3642325637
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One of the major challenges in tissue engineering is the translation of biological knowledge on complex cell and tissue behavior into a predictive and robust engineering process. Mastering this complexity is an essential step towards clinical applications of tissue engineering. This volume discusses computational modeling tools that allow studying the biological complexity in a more quantitative way. More specifically, computational tools can help in: (i) quantifying and optimizing the tissue engineering product, e.g. by adapting scaffold design to optimize micro-environmental signals or by adapting selection criteria to improve homogeneity of the selected cell population; (ii) quantifying and optimizing the tissue engineering process, e.g. by adapting bioreactor design to improve quality and quantity of the final product; and (iii) assessing the influence of the in vivo environment on the behavior of the tissue engineering product, e.g. by investigating vascular ingrowth. The book presents examples of each of the above mentioned areas of computational modeling. The underlying tissue engineering applications will vary from blood vessels over trachea to cartilage and bone. For the chapters describing examples of the first two areas, the main focus is on (the optimization of) mechanical signals, mass transport and fluid flow encountered by the cells in scaffolds and bioreactors as well as on the optimization of the cell population itself. In the chapters describing modeling contributions in the third area, the focus will shift towards the biology, the complex interactions between biology and the micro-environmental signals and the ways in which modeling might be able to assist in investigating and mastering this complexity. The chapters cover issues related to (multiscale/multiphysics) model building, training and validation, but also discuss recent advances in scientific computing techniques that are needed to implement these models as well as new tools that can be used to experimentally validate the computational results.