The Health Effects of Cannabis and Cannabinoids

by National Academies of Sciences, Engineering, and Medicine

Author	: National Academies of Sciences, Engineering, and Medicine
Publisher	: National Academies Press
Total Pages	: 487
Release	: 2017-03-31
Genre	: Science
ISBN	: 0309453070

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Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively. Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agendaâ€"outlining gaps in current knowledge and opportunities for providing additional insight into these issuesâ€"that summarizes and prioritizes pressing research needs.

Marijuana As Medicine?

by Institute of Medicine

Author	: Institute of Medicine
Publisher	: National Academies Press
Total Pages	: 216
Release	: 2000-12-30
Genre	: Medical
ISBN	: 0309065313

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Some people suffer from chronic, debilitating disorders for which no conventional treatment brings relief. Can marijuana ease their symptoms? Would it be breaking the law to turn to marijuana as a medication? There are few sources of objective, scientifically sound advice for people in this situation. Most books about marijuana and medicine attempt to promote the views of advocates or opponents. To fill the gap between these extremes, authors Alison Mack and Janet Joy have extracted critical findings from a recent Institute of Medicine study on this important issue, interpreting them for a general audience. Marijuana As Medicine? provides patientsâ€"as well as the people who care for themâ€"with a foundation for making decisions about their own health care. This empowering volume examines several key points, including: Whether marijuana can relieve a variety of symptoms, including pain, muscle spasticity, nausea, and appetite loss. The dangers of smoking marijuana, as well as the effects of its active chemical components on the immune system and on psychological health. The potential use of marijuana-based medications on symptoms of AIDS, cancer, multiple sclerosis, and several other specific disorders, in comparison with existing treatments. Marijuana As Medicine? introduces readers to the active compounds in marijuana. These include the principal ingredient in Marinol, a legal medication. The authors also discuss the prospects for developing other drugs derived from marijuana's active ingredients. In addition to providing an up-to-date review of the science behind the medical marijuana debate, Mack and Joy also answer common questions about the legal status of marijuana, explaining the conflict between state and federal law regarding its medical use. Intended primarily as an aid to patients and caregivers, this book objectively presents critical information so that it can be used to make responsible health care decisions. Marijuana As Medicine? will also be a valuable resource for policymakers, health care providers, patient counselors, medical faculty and studentsâ€"in short, anyone who wants to learn more about this important issue.

Marijuana and Medicine

by Institute of Medicine

Author	: Institute of Medicine
Publisher	: National Academies Press
Total Pages	: 288
Release	: 1999-07-10
Genre	: Medical
ISBN	: 0309071550

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The medical use of marijuana is surrounded by a cloud of social, political, and religious controversy, which obscures the facts that should be considered in the debate. This book summarizes what we know about marijuana from evidence-based medicineâ€"the harm it may do and the relief it may bring to patients. The book helps the reader understand not only what science has to say about medical marijuana but also the logic behind the scientific conclusions. Marijuana and Medicine addresses the science base and the therapeutic effects of marijuana use for medical conditions such as glaucoma and multiple sclerosis. It covers marijuana's mechanism of action, acute and chronic effects on health and behavior, potential adverse effects, efficacy of different delivery systems, analysis of the data about marijuana as a gateway drug, and the prospects for developing cannabinoid drugs. The book evaluates how well marijuana meets accepted standards for medicine and considers the conclusions of other blue-ribbon panels. Full of useful facts, this volume will be important to anyone interested in informed debate about the medical use of marijuana: advocates and opponents as well as policymakers, regulators, and health care providers.

Cannabinoids As Therapeutic Agents

by Raphael Mechoulam

Author	: Raphael Mechoulam
Publisher	: CRC Press
Total Pages	: 276
Release	: 2019-06-13
Genre	: Medical
ISBN	: 0429536267

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Published in 1986: The plant Cannabis sativa L. and its numerous preparations have been used as therapeutic agents for millenia. In the present book, the editor has tried to summarize the use in the past, to present an overview of modern research and applications to predict future developments.

Imaging of the Human Brain in Health and Disease

by Philip Seeman

Author	: Philip Seeman
Publisher	: Elsevier
Total Pages	: 534
Release	: 2013-11-15
Genre	: Science
ISBN	: 012418684X

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Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease. - A focused introduction to imaging healthy and diseased brains - Focuses on the primary neurotransmitter release - Includes sigma, acetylcholine, opioid, and dopamine receptors - Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease

Medicinal Cannabis and CBD in Mental Healthcare

by Kylie O'Brien

Author	: Kylie O'Brien
Publisher	: Springer Nature
Total Pages	: 591
Release	: 2021-10-27
Genre	: Medical
ISBN	: 3030785599

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This book functions as a clinician’s guide to the use of cannabidiol (CBD) in the treatment of mental health conditions. It conveys the scientific evidence of efficacy of CBD as well as THC and addresses the social stigma attached to its medical use. The book describes the endocannabinoid system, how stress and the endocannabinoid system interact and key constituents, pharmacokinetics and safety aspects of medicinal cannabis, focusing on CBD and THC. Chapters on specific mental health conditions describe the underpinning pathomechanisms including how the endocannabinoid system is involved, and summarises the scientific evidence including animal and human research for the use of CBD and THC in treatment of such conditions. Topics covered include anxiety, depression, post-traumatic stress disorder, insomnia, Alzheimer's Disease and autism spectrum disorder. Chapters also discuss treatment guidelines and case studies. Unique and focused, Medicinal Cannabis and CBD in Mental Healthcare is an invaluable reference for medical practitioners seeking to adopt CBD-use in their treatment plans.

Marijuana Gateway to Health

by Clint Werner

Author	: Clint Werner
Publisher	:
Total Pages	: 232
Release	: 2011
Genre	: Health & Fitness
ISBN	: 9780983426189

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"Learn how ingesting cannabinoids, the unique compounds found in the cannabis plant, can protect your health. Research reveals that: longterm marijuana smokers have a reduced risk for developing lung cancer ; the cannabinoid THC suppressed a variety of cancers and higher doses led to greated protection and longer life ; THC is effective for reducing the brain damage associated with Alzheimer's disease ; cannabinoids stimulate the production of healthy new brain cells."--Back cover.

The Complex Connection between Cannabis and Schizophrenia

by Michael T. Compton

Author	: Michael T. Compton
Publisher	: Academic Press
Total Pages	: 364
Release	: 2017-08-25
Genre	: Medical
ISBN	: 0128051833

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The Complex Connection between Cannabis and Schizophrenia provides an in-depth overview of the current state of research into the role that cannabis plays in schizophrenia, covering both the pathophysiological and the pharmacological implications. It addresses the epidemiology of cannabis use and the risks associated with its use, the biological aspects of the drug, its effects on the brain and the pharmacological possibilities of using cannabidiol to treat schizophrenia. It is the only book on the market devoted exclusively to examining the links between this very commonly used (and misused) drug and a specific set of devastating psychiatric illnesses, providing a comprehensive guide to our current understandings of this relationship. Marijuana is the most commonly used illicit drug globally, and is becoming increasingly decriminalized and even legalized worldwide. Among the numerous mental-health concerns related to the drug, there is mounting evidence of an intricate link between cannabis use and schizophrenia and related psychotic disorders. At the same time, there is promising evidence to suggest that cannabidiol, one of the many compounds found in cannabis that activates the brain's cannabinoid receptors, could prove to be an effective antipsychotic to treat schizophrenia. - Synthesizes existing knowledge about the confusing, but crucial, relationship between cannabis use and schizophrenia symptoms - Provides a comprehensive overview of the neurobiological mechanisms of cannabis use and its effects on the brain, including an exploration of the endocannabinoid system - Examines the promising evidence suggesting cannabidiol as an effective antipsychotic treatment for schizophrenia - Aids readers studying the neurobiological underpinning of cannabis addiction and psychosis in determining directions for their own future research

Cannabis Healing

by Franjo Grotenhermen

Author	: Franjo Grotenhermen
Publisher	: Simon and Schuster
Total Pages	: 290
Release	: 2020-09-22
Genre	: Health & Fitness
ISBN	: 1620558327

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Everything you need to know to use cannabinoids safely and effectively for better health and healing of a wide range of conditions • Explains the biochemistry of cannabinoids and shows how they interact with the human body • Offers a complete discussion of safe use, possible side effects, contraindications, and precautions, including during pregnancy and chemotherapy • Explores the use of CBD to treat seizures, anxiety, muscular disorders, and psychotic states and the use of THC to treat schizophrenia, Alzheimer’s, ADHD, Tourette’s, Parkinson’s, depression, COPD, and chronic pain, among many other physical, neurological, and emotional conditions In this authoritative yet practical guide to the healing properties of cannabis and cannabinoids such as THC and CBD, Franjo Grotenhermen, M.D., explores how to use these substances to treat a wide range of physical and emotional conditions. Dr. Grotenhermen first examines the history of marijuana as medicine, including its important role in U.S. medical practice during the 19th century. He explains the biochemistry of cannabinoids and shows how they interact with the human body, including a look at cannabinoid receptors and how cannabinoids occur naturally in the body. The author then draws on his years of experience legally treating patients in Germany as well as numerous research studies and tests to provide an in-depth guide to the many healing applications for cannabis and its derivatives. The therapeutic applications covered include the use of CBD to treat seizures, epilepsy, anxiety, several forms of cancer, muscular disorders, and psychotic states and the use of THC to treat schizophrenia, Alzheimer’s, ADHD, Tourette’s, Parkinson’s, impotence, depression, lupus, COPD, and chronic pain, among many other physical, neurological, and emotional conditions. The author examines the various cannabis-derived medications available, such as Cannabinol, Dronabinol, and Marinol, and the main methods of administering cannabis. He offers a complete discussion of safe use, possible side effects, contraindications, and precautions (including during pregnancy and chemotherapy), alongside research data that confirms cannabis as one of the least toxic substances in existence. Written by a practicing physician, this guide provides everything you need to know to use cannabinoids safely and effectively for health and healing.