Combinatorial Chemistry

Combinatorial Chemistry
Author: Stephen R. Wilson
Publisher: John Wiley & Sons
Total Pages: 288
Release: 1997-03-28
Genre: Medical
ISBN: 9780471126874

The new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation. Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes: * Concepts and terms of combinatorial chemistry * Polymer-supported synthesis of organic compounds * Macro beads as microreactors * Solid-phase methods in combinatorial chemistry * Encoded combinatorial libraries, including Rf-encoding of synthesis beads * Strategies for combinatorial libraries of oligosaccharides * Combinatorial libraries of peptides, proteins, and antibodies using biological systems. While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.

Handbook of Combinatorial Chemistry

Handbook of Combinatorial Chemistry
Author: K. C. Nicolaou
Publisher: Wiley-VCH
Total Pages: 652
Release: 2002-04-29
Genre: Medical
ISBN:

In two volumes, this comprehensive handbook provides coverage of the whole area of combinatorial synthetic chemistry, including compound library design and synthesis.

Combinatorial Chemistry

Combinatorial Chemistry
Author: Nicholas K. Terrett
Publisher:
Total Pages: 204
Release: 1998
Genre: Combinatorial chemistry
ISBN: 9780198502197

Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context.It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This is the first single author book in this important, growing field and it describes thebeneficial impact of combinatorial chemistry, especially for the discovery and optimisation of biologically active molecules. This concise and comprehensive overview of combinatorial techniques is an essential text for final year undergraduates, postgraduates, academics and industrialists inchemistry, bio-orgainc chemistry, medicinal chemistry and drug discovery. It provides an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in this field.

Combinatorial Synthesis of Natural Product-Based Libraries

Combinatorial Synthesis of Natural Product-Based Libraries
Author: Armen M. Boldi
Publisher: CRC Press
Total Pages: 363
Release: 2006-05-16
Genre: Science
ISBN: 1420009273

Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinato

Combinatorial Chemistry and Technologies

Combinatorial Chemistry and Technologies
Author: Stanislav Miertus
Publisher: CRC Press
Total Pages: 597
Release: 2005-04-12
Genre: Medical
ISBN: 1420027840

Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the

Dynamic Combinatorial Chemistry

Dynamic Combinatorial Chemistry
Author: Joost N. H. Reek
Publisher: John Wiley & Sons
Total Pages: 211
Release: 2010-02-02
Genre: Science
ISBN: 9783527629718

This long-awaited first book on this exciting new field in organic and supramolecular chemistry explains the fundamentals as well as possible applications of DCC. Authored by the "Who's Who" of DCC it spans the whole range of topics: catalysts, sensors, polymers, ligands, receptors, concluding with a look at future developments and perspectives. All set to become the standard text in the field, this one-stop reference contains everything organic, catalytic, polymer, physical and biochemists need to know.

Dynamic Combinatorial Chemistry

Dynamic Combinatorial Chemistry
Author: Benjamin L. Miller
Publisher: John Wiley & Sons
Total Pages: 280
Release: 2009-12-30
Genre: Science
ISBN: 9780470551547

Effective techniques for applying Dynamic Combinatorial Chemistry In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science, and others. Bringing together a group of respected experts, this overview explains how chemists can apply DCC and fragment-based library methods to lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials science. Chapters cover: Basic theory Approaches to binding in proteins and nucleic acids Molecular recognition Self-sorting Catalyst discovery Materials discovery Analytical chemistry challenges A comprehensive, single-source reference about DCC methods and applications including aspects of fragment-based drug discovery, this is a core reference that will spark the development of new solutions and strategies for chemists building structure libraries and designing compounds and materials.

Combinatorial Chemistry

Combinatorial Chemistry
Author: John Abelson
Publisher: Elsevier
Total Pages: 546
Release: 1996
Genre: Combinatorial chemistry
ISBN: 9780121821685

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 260 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Key Features* Phage display libraries* Repression fusion proteins* Polysome libraries* Peptide libraries* Nucleic acid libraries* Other small molecule libraries.

Combinatorial Chemistry and Technology

Combinatorial Chemistry and Technology
Author: Stanislav Miertus
Publisher: CRC Press
Total Pages: 456
Release: 1999-07-01
Genre: Science
ISBN: 9781420000566

"Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular ""libraries."" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules."