The Endangered Species Act of 1973 (ESA) is one of the most cherished and reviled laws ever passed. It mandates protection and preservation of all the nation’s species and biodiversity, whatever the cost. It has been a lightning rod for controversy and conflicts between industry/business and environmentalists. In this volume, leading Endangered Species Act experts interpret and propose legislative and administrative changes to prepare the ESA for future challenges. They explore regulations on avoiding harm to and producing benefits for species, cooperation between state and federal agencies, scientific analyses, and the necessary politics to enact their ideas. This is a call to action to chart an enlightened future for the Endangered Species Act that embraces the nation’s moral commitment of 50 years ago to address species extinction constructively, mindful of biodiversity, and as a fixture among the nation’s values and needs. The interconnected web of life includes all living species that depend on each other for survival, us among them. The stakes—our very future—are too high to ignore.