The work of Alain Connes has cut a wide swath across several areas of mathematics and physics. Reflecting its broad spectrum and profound impact on the contemporary mathematical landscape, this collection of articles covers a wealth of topics at the forefront of research in operator algebras, analysis, noncommutative geometry, topology, number theory and physics. Specific themes covered by the articles are as follows: entropy in operator algebras, regular $C^*$-algebras of integral domains, properly infinite $C^*$-algebras, representations of free groups and 1-cohomology, Leibniz seminorms and quantum metric spaces; von Neumann algebras, fundamental Group of $\mathrm{II}_1$ factors, subfactors and planar algebras; Baum-Connes conjecture and property T, equivariant K-homology, Hermitian K-theory; cyclic cohomology, local index formula and twisted spectral triples, tangent groupoid and the index theorem; noncommutative geometry and space-time, spectral action principle, quantum gravity, noncommutative ADHM and instantons, non-compact spectral triples of finite volume, noncommutative coordinate algebras; Hopf algebras, Vinberg algebras, renormalization and combinatorics, motivic renormalization and singularities; cyclotomy and analytic geometry over $F_1$, quantum modular forms; differential K-theory, cyclic theory and S-cohomology.