Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

Handbook of Oxidative Stress in Cancer: Therapeutic Aspects
Author: Sajal Chakraborti
Publisher: Springer Nature
Total Pages: 4078
Release: 2022-09-28
Genre: Medical
ISBN: 9811654220

This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy. ​

Handbook on Oxidative Stress

Handbook on Oxidative Stress
Author: Adolfo M. Reyes
Publisher: Nova Science Publishers
Total Pages: 0
Release: 2012
Genre: Oxidative stress
ISBN: 9781619421783

This book presents new research in the study of oxidative stress. Topics discussed include pharmacological treatments in myocardial ischemia-reperfusion injury; oxidative stress in neurodenegerative disorders, hyptertension, and the cardiovascular system; the role of antioxidant supplementation in ischemic stroke; mitochondria at the crossroads of cancer and oxidative stress; and the influence of aerobic exercise training on post-prandial oxidative stress.

Handbook of Oxidants and Antioxidants in Exercise

Handbook of Oxidants and Antioxidants in Exercise
Author: C. Sen
Publisher: Elsevier
Total Pages: 1219
Release: 2000-02-16
Genre: Science
ISBN: 0080538290

Interest in the science of exercise dates back to the time of ancient Greece. Today exercise is viewed not only as a leisurely activity but also as an effective preventive and therapeutic tool in medicine. Further biomedical studies in exercise physiology and biochemistry reports that strenuous physical exercise might cause oxidative lipid damage in various tissues. The generation of reactive oxygen species is elevated to a level that overwhelms the tissue antioxidant defense systems resulting in oxidative stress.The Handbook of Oxidants and Antioxidants in Exercise examines the different aspects of exercise-induced oxidative stress, its management, and how reactive oxygen may affect the functional capacity of various vital organs and tissues. It includes key related issues such as analytical methods, environmental factors, nutrition, aging, organ function and several pathophysiological processes.This timely publication will be of relevance to those in biomedical science and was designed to be readily understood by the general scientific audience.

Handbook of Arsenic Toxicology

Handbook of Arsenic Toxicology
Author: Swaran Jeet Singh Flora
Publisher: Academic Press
Total Pages: 752
Release: 2014-12-26
Genre: Science
ISBN: 0124199550

Throughout history, arsenic has been used as an effective and lethal poison. Today, arsenic continues to present a real threat to human health all over the world, as it contaminates groundwater and food supplies. Handbook of Arsenic Toxicology presents the latest findings on arsenic, its chemistry, its sources and its acute and chronic effects on the environment and human health. The book takes readings systematically through the target organs, before detailing current preventative and counter measures. This reference enables readers to effectively assess the risks related to arsenic, and provide a comprehensive look at arsenic exposure, toxicity and toxicity prevention. - Brings together current findings on the effects of arsenic on the environment and human health - Includes state-of-the-art techniques in arsenic toxicokinetics, speciation and molecular mechanisms - Provides all the information needed for effective risk assessment, prevention and countermeasure

Handbook of Antioxidants

Handbook of Antioxidants
Author: Lester Packer
Publisher: CRC Press
Total Pages: 732
Release: 2001-10-26
Genre: Medical
ISBN: 0824745108

Contains new and expanded material on antioxidants in beverages and herbal products, nitric oxide and selenium, and the effect of vitamin C on cardiovascular disease and of lipoic acid on aging, hyperglycemia, and insulin resistance! Offering over 4200 contemporary references-2000 more than the previous edition-the Second Edition of the Handbook of Antioxidants is an up-to-the-minute source for nutritionists and dietitians, cell biologists and biochemists, cardiologists, oncologists, dermatologists, and medical students in these disciplines.

Cancer Stem Cells and Signaling Pathways

Cancer Stem Cells and Signaling Pathways
Author: Surajit Pathak
Publisher: Elsevier
Total Pages: 703
Release: 2023-11-01
Genre: Science
ISBN: 0443132119

Cancer Stem Cells and Signaling Pathways explores the mechanism of cancer stem cell signaling pathways in cancer advancement, serving as an ideal reference guide for investigators with valuable answers to problems associated with anti-cancer treatments and an understanding of the crosstalk among the signaling pathways in CSC regulation. Despite recent advances in tumor therapy and a greater understanding of their biology, tumors continue to be a prevalent and fatal worldwide. According to a novel paradigm in tumor biology, a small percentage of the cells within a tumor known as cancer stem cells (CSCs) are predicted as a crucial population for tumor progression. - Presents cancer stem characteristics and their signaling pathways - Highlights the use of animal models for cancer research, the use of genetically modified stem cells to deliver antitumor agents, and the significance of stem cell signaling in drug discovery - Covers basic and translational research appropriate for scientists and clinicians exploring alternative treatments for various cancers

Computational Biology for Stem Cell Research

Computational Biology for Stem Cell Research
Author: Pawan Raghav
Publisher: Elsevier
Total Pages: 568
Release: 2024-01-12
Genre: Science
ISBN: 0443132216

Computational Biology for Stem Cell Research is an invaluable guide for researchers as they explore HSCs and MSCs in computational biology. With the growing advancement of technology in the field of biomedical sciences, computational approaches have reduced the financial and experimental burden of the experimental process. In the shortest span, it has established itself as an integral component of any biological research activity. HSC informatics (in silico) techniques such as machine learning, genome network analysis, data mining, complex genome structures, docking, system biology, mathematical modeling, programming (R, Python, Perl, etc.) help to analyze, visualize, network constructions, and protein-ligand or protein-protein interactions. This book is aimed at beginners with an exact correlation between the biomedical sciences and in silico computational methods for HSCs transplantation and translational research and provides insights into methods targeting HSCs properties like proliferation, self-renewal, differentiation, and apoptosis. - Modeling Stem Cell Behavior: Explore stem cell behavior through animal models, bridging laboratory studies to real-world clinical allogeneic HSC transplantation (HSCT) scenarios. - Bioinformatics-Driven Translational Research: Navigate a path from bench to bedside with cutting-edge bioinformatics approaches, translating computational insights into tangible advancements in stem cell research and medical applications. - Interdisciplinary Resource: Discover a single comprehensive resource catering to biomedical sciences, life sciences, and chemistry fields, offering essential insights into computational tools vital for modern research.

Stem Cells

Stem Cells
Author: Yogesh Kumar Verma
Publisher: Elsevier
Total Pages: 437
Release: 2023-11-29
Genre: Science
ISBN: 0323955460

Stem Cells: An Alternative Therapy for COVID-19 and Cytokine Storm provides mechanistic insights into the role of stem cells to combat COVID-19 outbreak and other pathologies where cytokines storm is the cause of concern for e.g., radiation exposure, multiple organ failure and sepsis. There has been an increase in number of cases of new diseases in the last decade, including mucormycosis, Zika virus, H1N1 influenza virus, among others. These diseases can be characterized by the induction of cytokine storm, which is mainly responsible for morbidity and mortality.Stem cell therapy has emerged as a potential treatment for viral diseases, including, but not limited to, COVID-19. Interestingly, clinical trials in patients with COVID-19 complications depicted faster recovery in patients post mesenchymal stem cells therapy owing to the decreased cytokines levels, anti-viral effects and regeneration of the infected tissue. - Evaluates the role of MSCs to combat cytokine storm, the challenges regarding COVID-19 therapy and how they can be countered using stem cells, and the risk of opportunistic infections post COVID-19 - Presents how stem cell therapy has emerged as a potential treatment for viral diseases, including, but not limited to, COVID-19 - Provides a detailed understanding of the novel coronavirus, with an emphasis on therapeutic aspects

Phytopharmaceuticals and Biotechnology of Herbal Plants

Phytopharmaceuticals and Biotechnology of Herbal Plants
Author: Sachidanand Singh
Publisher: CRC Press
Total Pages: 521
Release: 2022-12-28
Genre: Health & Fitness
ISBN: 1000811298

Plant-based drugs play an important role in all cultures and have been crucial in maintaining health and fighting diseases, and by using contemporary methods of biotechnology, plants with explicit chemical compositions are propagated and genetically upgraded for the mining of pharmaceuticals. Phytopharmaceuticals and Biotechnology of Herbal Plants presents the latest advances in the development of transgenic plants, covering phototherapeutics, secondary metabolite production, metabolomics, metabolic engineering, bioinformatics, quality control of herbal plant products, crop improvement using various breeding techniques, tissue culture techniques, and the future of phytopharmaceuticals. Features: Describes developments and applications of phytopharmaceuticals of herbal plants. Highlights the importance of phytopharmaceutical of plants and potential applications in the food and pharma industries. Provides an overview of research on key anticancer drugs to elucidate the biotechnological approaches for their production in cell cultures. Places special emphasis on the biosynthetic pathway mapping and metabolic engineering. Phytopharmaceuticals and Biotechnology of Herbal Plants will be an invaluable resource to academics and researchers associated with plant science, herbal drug manufacturers, and phytochemists.