Heavily dominated by the sector of information and communication technologies, economic organizations pursue digital transformation as a differentiating factor and source of competitive advantage. Understanding the challenges of digital transformation is critical to managers to ensure business sustainability. However, there are some problems, such as architecture, security, and reliability, among others, that bring with them the need for studies and investments in this area to avoid significant financial losses. Digital transformation encompasses and challenges many areas, such as business models, organizational structures, human privacy, management, and more, creating a need to investigate the challenges associated with it to create a roadmap for this new digital transformation era. The Handbook of Research on Digital Transformation and Challenges to Data Security and Privacy presents the main challenges of digital transformation and the threats it poses to information security and privacy, as well as models that can contribute to solving these challenges in economic organizations. While highlighting topics such as information systems, digital trends, and information governance, this book is ideally intended for managers, data analysts, cybersecurity professionals, IT specialists, practitioners, researchers, academicians, and students working in fields that include digital transformation, information management, information security, information system reliability, business continuity, and data protection.