With increasingly interconnected educational and employment ecosystems, credential innovations are trailblazing multiple pathways to professions at a pivotal moment of rapid change. In the current state of credential proliferation, the quest for simultaneous improvement of quality and value reflects heightened cross-sector interests, while at the same time the quest for concurrent enhancement of access and success remains. With the evolving educational models, technologies, and organizations, credential innovations will continue to serve as powerful catalysts in realizing the great promise for inclusive pathways to professions. The Handbook of Research on Credential Innovations for Inclusive Pathways to Professions surveys the state of credential innovations, examines trends and issues, and explores models and strategies with case studies across sectors and disciplines. The 21 chapters are organized in three sections. Section I, Credential Innovations Amid Evolving Ecosystems, features a powerful array of change theories-in-action with topics ranging from conceptual re-visioning to organizational restructuring and programmatic reengineering within evolving ecosystems. Section II, Credential Innovations and Propositions Across Sectors, spotlights diverse approaches to and propositions of credentials within complex socio-economic landscapes across education, business, and technology industries. Section III, Credential Innovation Models and Strategies, showcases institutional innovations ranging from model developments, pedagogical approaches, and personalized engagements to outcome measurements and strategies for sustainable implementation. Lessons learned and implications are explored to share promising practices, inform current development, and influence future policies toward inclusive excellence in education and the workplace.