After an unending series of bizarre accidents continues to daily claim the lives of drivers near Reno, Nevada, widespread panic ensues and people flee the area en masse. Nineteen-year-old student Jenny Allison Bradley joins her cousin Mark and his girlfriend in their escape via Mark's car. Totally exhausted, Jenny falls into a deep sleep in the back seat, where she has a long, horrific nightmare. In her dream she sees everything from the gang rape of a girl to the graphic imagery of an ancient people making human sacrifices of young girls. But the dream is more than her imagination at work. It is real. Jenny's nightmare is being spun by the cosmic hand of an ancient Aztec deity who is using the dream to shake Jenny into helping save the earth from an evil goddess called Tezcatlipoca, the cruel entity responsible for all the recent accidents in Nevada. Through the nightmare, Jenny learns how the evil goddess was released by a modern-day sorceress who casts a spell after her daughter is gang raped and murdered. It is up to Jenny to stop the carnage on Haunted Highway before the car she is traveling in reaches the spot where the evil spirit waits.