| Author | : Martin Coward |
| Publisher | : Routledge |
| Total Pages | : 176 |
| Release | : 2008-09-30 |
| Genre | : Architecture |
| ISBN | : 1134043937 |
Developing the concept of urbicide – the deliberate destruction of cities – Martin Coward outlines a theoretical understanding of the urban condition at stake in such violence. The first comprehensive analysis, Coward argues that it is necessary to address the widespread and deliberate destruction of buildings as a distinct form of political violence.
| Author | : Agency for Health Care Research and Quality (U.S.) |
| Publisher | : Government Printing Office |
| Total Pages | : 236 |
| Release | : 2013-02-21 |
| Genre | : Medical |
| ISBN | : 1587634236 |
This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
| Author | : Boris G. Kuznetsov |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 460 |
| Release | : 2013-06-29 |
| Genre | : Science |
| ISBN | : 9400945906 |
Boris Kuznetsov was a scientist among humanists, a philosopher among scientists, a historian for those who look to the future, an optimist in an age of sadness. He was steeped in classical European culture, from earliest times to the latest avant-garde, and he roamed through the ages, an inveterate time-traveller, chatting and arguing with Aristotle and Descartes, Heine and Dante, among many others. Kuznetsov was also, in his intelligent and thoughtful way, a Marxist scholar and a practical engineer, a patriotic Russian Jew of the first sixty years of the Soviet Union. Above all he meditated upon the revolutionary developments of the natural sciences, throughout history to be sure but particularly in his own time, the time of what he called 'non-classical science', and of his beloved and noblest hero, Albert Einstein. Kuznetsov was born in Dnepropetrovsk on October 5, 1903 (then Yekaterinoslav). By early years he had begun to teach, first in 1921 at an institute of mining engineering and then at other technological institutions. By 1933 he had received a scientific post within the Academy of Science of the U. S. S. R. , and then at the end of the Second World War he joined several colleagues at the new Institute of the History of Science and Technology. For more than 40 years he worked there until his death two years ago.
| Author | : Thomas Skuzinski |
| Publisher | : Routledge |
| Total Pages | : 212 |
| Release | : 2017-09-18 |
| Genre | : Political Science |
| ISBN | : 1315304015 |
Creating metropolitan regions that are more efficient, equitable, and sustainable depends on the willingness of local officials to work together across municipal boundaries to solve large-scale problems. How do these local officials think? Why do they only sometimes cooperate? What kind of governance do they choose in the face of persistent problems? The Risk of Regional Governance offers a new perspective on these questions. Drawing on theory from sociology and anthropology, it argues that many of the most important cooperative decisions local officials make—those about land use planning and regulation—are driven by heuristic, biased reasoning driven by cultural values. The Risk of Regional Governance builds a sociocultural collective action framework, and supports it with rich survey and interview data from hundreds of local elected officials serving in the suburbs of Detroit and Grand Rapids, Michigan. It is a story of the Rust Belt, of how local officials think about their community and the region, and—most importantly—of how we might craft policies that can overcome biases against regional governance.
| Author | : Jurek Kolasa |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 344 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 1461230624 |
An attractive, promising, and frustrating feature of ecology is its complex ity, both conceptual and observational. Increasing acknowledgment of the importance of scale testifies to the shifting focus in large areas of ecology. In the rush to explore problems of scale, another general aspect of ecolog ical systems has been given less attention. This aspect, equally important, is heterogeneity. Its importance lies in the ubiquity of heterogeneity as a feature of ecological systems and in the number of questions it raises questions to which answers are not readily available. What is heterogeneity? Does it differ from complexity? What dimensions need be considered to evaluate heterogeneity ade quately? Can heterogeneity be measured at various scales? Is heterogeneity apart of organization of ecological systems? How does it change in time and space? What are the causes of heterogeneity and causes of its change? This volume attempts to answer these questions. It is devoted to iden tification of the meaning, range of applications, problems, and methodol ogy associated with the study of heterogeneity. The coverage is thus broad and rich, and the contributing authors have been encouraged to range widely in discussions and reflections. vi Preface The chapters are grouped into themes. The first group focuses on the conceptual foundations (Chapters 1-5). These papers exarnine the meaning of the term, historical developments, and relations to scale. The second theme is modeling population and interspecific interactions in hetero geneous environments (Chapters 6 and 7).
| Author | : Derek Gordon |
| Publisher | : Springer |
| Total Pages | : 352 |
| Release | : 2020-12-17 |
| Genre | : Medical |
| ISBN | : 9783030611200 |
Heterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affected and unaffected individuals. Still, most statistical genetic association analyses, designed to map genes for diseases and other genetic traits, ignore this phenomenon. In this book, we document methods that incorporate heterogeneity into the design and analysis of genetic and genomic association data. Among the key qualities of our developed statistics is that they include mixture parameters as part of the statistic, a unique component for tests of association. A critical feature of this work is the inclusion of at least one heterogeneity parameter when performing statistical power and sample size calculations for tests of genetic association. We anticipate that this book will be useful to researchers who want to estimate heterogeneity in their data, develop or apply genetic association statistics where heterogeneity exists, and accurately evaluate statistical power and sample size for genetic association through the application of robust experimental design.
| Author | : Rima Franklin |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 339 |
| Release | : 2007-09-04 |
| Genre | : Science |
| ISBN | : 1402062168 |
This volume highlights recent advances that have contributed to our understanding of spatial patterns and scale issues in microbial ecology. The book brings together research conducted at a range of spatial scales (from μm to km) and in a variety of different types of environments. These topics are addressed in a quantitative manner, and a primer on statistical methods is included. In soil ecosystems, both bacteria and fungi are discussed.
| Author | : Vered Stearns |
| Publisher | : Springer |
| Total Pages | : 291 |
| Release | : 2016-03-17 |
| Genre | : Medical |
| ISBN | : 3319229095 |
This volume provides a comprehensive review of established and novel biomarkers across the continuum of breast cancer. The volume covers topics related to breast cancer risk and prevention, prediction of response to today’s standard therapies, and markers capable of influencing treatment decisions in the near future. Chapter authors combine their wide-ranging expertise to review the current status of the biomarker and to offer their individual perspectives on how biomarkers may be used in future treatments and research. Breast cancer continues to be the most common malignancy diagnosed in women in the Western world. While there are multiple treatment approaches for breast cancer, today more than ever we recognize that each tumor is unique. The challenge ahead is to consider how to best use validated and novel biomarkers to select the most appropriate treatment(s) for individual patients.
