"Human exploration of space contains many ethical challenges. Future long-term space missions will generate specific problems and place new demands on humanity. One of them is the concept of human enhancement, primarily through gene editing, for the implementation of long-term space missions. In this book, I hypothesize that large-scale application of human enhancement may be necessary to enable space exploration and exploitation. The book discusses the many arguments for and against human genetic modification for space missions. It also considers the most controversial type of modification, germline gene editing. In the book I present many arguments in favor of applying even radical and considered controversial forms of human enhancements today. The book shows that the environment of future space missions is a unique and different ethical environment from Earth's and requires a modified bioethical approach. The bioethics of space missions should be syncretic, issue-driven, and highly dependent on the purpose of space missions. In the book, I point out the importance of discussing future scenarios of human development. Space bioethics is presented as part of futures studies. The book considers futures of humanity in space that are possible, probable, preferable, but also dystopian. The aim of these considerations is to prevent the development of these worst-case scenarios. The book suggests that we should look to the development of biomedicine with greater optimism and hope. Human enhancement via gene editing for space missions is presented as a pragmatic tool rooted in the principle of well-being"--