Inflammation and Lung Cancer

by Steven M. Dubinett

Author	: Steven M. Dubinett
Publisher	: Springer
Total Pages	: 0
Release	: 2016-10-09
Genre	: Medical
ISBN	: 9781493945115

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In recent years there have been various discoveries connecting inflammation and lung cancer and clearly there is growing interest in this area of cancer research. The link between unresolved inflammation and cancer has been well established with estimates that 15% of cancer deaths are inflammation‐related. Evidence for this link includes the following: a) some inflammatory diseases are associated with increased risk of cancer development; b) inflammatory mediators are present surrounding and within most tumors; c) overexpression of inflammatory cytokines increases cancer development and progression in murine studies; d) inhibition of inflammatory mediators decreases cancer development and progression; and e) the use of non‐steroidal anti‐inflammatory drugs (NSAIDs) has been found to decrease cancer incidence and delay progression. The volume will present aspects of the inflammatory tumor microenvironment (TME), its many roles in tumor progression and metastasis, including creation of a hypoxic environment, increased angiogenesis and invasion, changes in expression of micro‐RNAs (miRNAs) and an increase in a stem cell phenotype. The book will also cover the mechanisms of inflammatory mediators. Chronic overexpression of inflammatory mediators in the TME, as seen in smokers and patients with non‐small cell lung cancer (NSCLC), can also lead to increased tumor initiation, progression, invasion and metastasis. The volume will provide a comprehensive perspective of the latest findings and summaries of progress made regarding inflammation and its connection to lung cancer.

Inflammation and Cancer

by Bharat B. Aggarwal

Author	: Bharat B. Aggarwal
Publisher	: Springer
Total Pages	: 489
Release	: 2014-05-12
Genre	: Medical
ISBN	: 3034808372

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This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Inflammation and Cancer

by Brendan J. Jenkins

Author	: Brendan J. Jenkins
Publisher	: Humana
Total Pages	: 0
Release	: 2023-06-25
Genre	: Medical
ISBN	: 9781071633335

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This second edition volume expands on the previous edition with an update on the broad spectrum of research models, techniques, and protocols used in laboratories by basic and clinical researchers. The chapters in this book are divided into two parts. Part One discusses the latest findings on the development and characterization of representative research models for chronic immune-based diseases and inflammation-associated cancers. Part Two covers biochemical, molecular, and cellular biological techniques that are commonly used to dissect the molecular mechanisms and cellular processes that drive the pathogenesis of certain disease states. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Inflammation and Cancer: Methods and Protocols, Second Edition is a valuable resource for those with a diverse range of laboratory-based experience, ranging from novice undergraduate students to established basic or clinical researchers who wish to diversify their existing portfolio of practical knowledge in the field.

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems

by Kamal Dua

Author	: Kamal Dua
Publisher	: Academic Press
Total Pages	: 620
Release	: 2020-08-04
Genre	: Technology & Engineering
ISBN	: 0128208880

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Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development. - Explores recent perspectives and challenges regarding the management and diagnosis of chronic respiratory diseases - Provides insights into how advanced drug delivery systems can be effectively formulated and delivered for the management of various pulmonary diseases - Includes the most recent information on diagnostic methods and treatment strategies using controlled drug delivery systems (including nanotechnology)

How Tobacco Smoke Causes Disease

by United States. Public Health Service. Office of the Surgeon General

Author	: United States. Public Health Service. Office of the Surgeon General
Publisher	:
Total Pages	: 728
Release	: 2010
Genre	: Government publications
ISBN	:

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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Wound Healing

by Kursad Turksen

Author	: Kursad Turksen
Publisher	: John Wiley & Sons
Total Pages	: 320
Release	: 2018-02-21
Genre	: Science
ISBN	: 1119282489

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A comprehensive resource on the recent developments of stem cell use in wound healing With contributions from experts in the field, Wound Healing offers a thorough review of the most recent findings on the use of stem cells to heal wounds. This important resource covers both the basic and translational aspects of the field. The contributors reveal the great progress that has been made in recent years and explore a wide range of topics from an overview of the stem cell process in wound repair to inflammation and cancer. They offer a better understanding of the identities of skin stem cells as well as the signals that govern their behavior that contributes to the development of improved therapies for scarring and poorly healing wounds. Comprehensive in scope, this authoritative resource covers a wealth of topics such as: an overview of stem cell regeneration and repair, wound healing and cutaneous wound healing, the role of bone marrow derived stems cells, inflammation in wound repair, role and function of inflammation in wound repair, and much more. This vital resource: Provides a comprehensive overview of stem cell use in wound healing, including both the basic and translational aspects of the field Covers recent developments and emerging subtopics within the field Offers an invaluable resource to clinical and basic researchers who are interested in wound healing, stem cells, and regenerative medicine Contains contributions from leading experts in the field of wound healing and care Wound Healing offers clinical researchers and academics a much-needed resource written by noted experts in the field that explores the role of stem cells in the repair and restoration of healing wounds.

Systems Biology of Cancer

by Sam Thiagalingam

Author	: Sam Thiagalingam
Publisher	: Cambridge University Press
Total Pages	: 597
Release	: 2015-04-09
Genre	: Mathematics
ISBN	: 0521493390

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An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

The Link Between Inflammation and Cancer

by Angus G. Dalgleish

Author	: Angus G. Dalgleish
Publisher	: Springer Science & Business Media
Total Pages	: 260
Release	: 2006-03-05
Genre	: Medical
ISBN	: 0387262830

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A link between inflammation and cancer has been established many years ago, yet it is only recently that the potential significance of this connection has become apparent. Although several examples of chronic inflammatory conditions, often induced by persistent irritation and/or infection, developing into cancer have been known for some time, there has been a notable resistance to contemplate the possibility that this association may apply in a causative way to other cancers. Examples for such progression from chronic inflammation to cancer are colon carcinoma developing with increased frequency in patients with ulcerative colitis, and the increased incidence of bladder cancer in patients suffering from chronic Schistosoma infection. Inflammation and cancer have been recognized to be linked in another context for many years, i.e., with regards to pathologies resembling chronic lacerations or 'wounds that do not heal.' More recently, the immunology of wound healing has given us clues as to the mechanistic link between inflammation and cancer, in as much as wounds and chronic inflammation turn off local cell-mediated immune responses and switch on growth factor release as well the growth of new blood vessels - angiogenesis. Both of these are features of most types of tumours, which suggest that tumours may require an immunologically shielded milieu and a growth factor-rich environment.

Smoking and Lung Cancer

by Evelyn N. Powers

Author	: Evelyn N. Powers
Publisher	: Nova Science Pub Incorporated
Total Pages	: 247
Release	: 2009
Genre	: Medical
ISBN	: 9781606923672

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Smoking responsible for 90% of cancer deaths. Incidence of lung cancer is rising. Lung cancer is responsible for more cancer deaths than colorectal cancer, breast cancer, and prostate cancer combined. Lung cancer primarily strikes people over age 45. By the time that an individual develops symptoms, spread has usually occurred. Lung cancer is directly related to smoking. Over 40 carcinogens have been identified in cigarette smoke. The risk of developing lung cancer is directly related to the number of cigarettes smoked. The change in consumption from unfiltered high tar cigarettes to filtered low tar cigarettes parallels the change in incidence from squamous cell carcinoma to adenocarcinoma. There is a long interval between quitting smoking and elimination of lung cancer risk. Up to 40% of newly diagnosed lung cancer occurs in former smokers. (median abstinence duration 9 years). This book presents the latest research in the field from around the world.