The Handbook of Local and Regional Development provides a comprehensive statement and reference point for local and regional development. The scope of this Handbook’s coverage and contributions engages with and reflects upon the politics and policy of how we think about and practise local and regional development, encouraging dialogue across the disciplinary barriers between notions of ‘local and regional development’ in the Global North and ‘development studies’ in the Global South. This Handbook is organized into seven inter-related sections, with an introductory chapter setting out the rationale, aims and structure of the Handbook. Section one situates local and regional development in its global context. Section two establishes the key issues in understanding the principles and values that help us define what is meant by local and regional development. Section three critically reviews the current diversity and variety of conceptual and theoretical approaches to local and regional development. Section four address questions of government and governance. Section five connects critically with the array of contemporary approaches to local and regional development policy. Section six is an explicitly global review of perspectives on local and regional development from Africa, Asia-Pacific, Europe, Latin America and North America. Section seven provides reflection and discussion of the futures for local and regional development in an international and multidisciplinary context. With over forty contributions from leading international scholars in the field, this Handbook provides critical reviews and appraisals of current state-of-the-art conceptual and theoretical approaches and future developments in local and regional development.