A multidimensional approach to entrepreneurship, especially in the post-COVID-19 era, will have an important influence on the state of business and government, especially when considering the effects of technological development, innovation, glocalization, and nationalization policies that need to be adopted for inclusive sustainable growth, as well as the enhanced and efficient utilization of global resources. That means there is likely to be a shift in how entrepreneurship development and entrepreneurial opportunities will be perceived, developed, and resourced. The question is how to sustain SMEs and entrepreneurial innovation in the post-COVID-19 era. Thus, comprehensive research and knowledge on designing policies and approaches to ensure the sustainability of SMEs and entrepreneurial innovation in post-pandemic times are essential to sustain, stimulate, and foster SMEs, entrepreneurship, and entrepreneurial innovations. The Handbook of Research on Sustaining SMEs and Entrepreneurial Innovation in the Post-COVID-19 Era provides research dedicated to entrepreneurship with a special emphasis on the sustainability of SMEs and entrepreneurial innovations in the post-COVID-19 era. It provides discussion and the exchange of information on principles, strategies, models, techniques, methodologies, and applications of entrepreneurship in the post-COVID-19 era in the field of public and private organizations. The chapters communicate the latest developments and thinking on the entrepreneurship subject worldwide by drawing on the latest developments, ideas, research, and best practice to examine the implications of the changes taking place due to COVID-19. This book is ideally intended for entrepreneurs, global organizations, small and medium-sized enterprises, managers, executives, government officials, policymakers, researchers, academicians, and students who are interested in learning about, designing, or implementing policies that are more effective in the post-pandemic era.