This book uncovers the multiple layers of challenges posed to achieve sustainable human health and improves the understanding of interactive areas set by the UN Sustainable Development Goals (1) no poverty, (2) zero hunger, (3) good health and wellbeing, (6) clean water and sanitation, and (11) sustainable cities and communities. The book focuses on conceptual understanding, food, nutrition, lifestyle, and their integration to reinforce the ideas of holistic health principles.' The most important drivers of sustainable health are food, nutrition, and lifestyle. Healthy food is a basic need of human beings. In under-developed regions, people are underweight and facing malnutrition, with a prevalence of deficiency diseases due to low intake of micro-nutrients such as vitamin A, iodine, and protein among others. A good diet as well as lifestyle has a tremendous bearing on a person’s health, emotional stability, and enthusiasm for life. The global coronavirus pandemic has brought unimaginable devastation and hardship in all corners of the globe, questioning the existing healthcare services, health policies, and health planning across the developed and developing countries. It has also exposed the lacunae in understanding health, the base of human happiness. The global community needs to gravely ponder the health issues we are facing and explore sustainable solutions for health recovery and the wellbeing of humanity.