Lung Cancer Unveiled: From Research to Personalized Care

by Dr. Spineanu Eugenia

Author	: Dr. Spineanu Eugenia
Publisher	: Dr. Spineanu Eugenia
Total Pages	: 227
Release	: 2024-03-03
Genre	: Medical
ISBN	:

GET BOOK

Unlock the secrets of lung cancer in "Lung Cancer Unveiled: From Research to Personalized Care." Delve into the world of cutting-edge research, revolutionary treatments, and the global efforts that are reshaping the landscape of lung cancer care. In this comprehensive treatise, you'll embark on a journey through the intricate web of lung cancer, exploring its multifaceted nature and the global collaborations that are driving progress. Discover how epidemiology and risk factors play a pivotal role in shaping the incidence of lung cancer and how early detection technologies are transforming the odds for patients. With a focus on personalized treatment approaches, this treatise unveils the power of precision medicine in lung cancer care. Explore genetic profiling, molecular biomarkers, and immunotherapy innovations that are redefining how we combat this deadly disease. Learn how personalized treatment strategies are offering patients not just hope, but real outcomes that extend survival and enhance quality of life. But "Lung Cancer Unveiled" goes beyond the science. It delves into the global efforts, advocacy, and healthcare policies that are shaping the future of lung cancer care. Gain insights into the collaborative initiatives, research advancements, and challenges that researchers, clinicians, and organizations worldwide are tackling head-on. If you seek knowledge, hope, and actionable insights into lung cancer, this treatise is your comprehensive guide. With its SEO-optimized content, it's designed not just to inform but also to reach those who need it most. Join us on this journey through the world of lung cancer research, and discover how we're unveiling a brighter future for patients and their families.

Economic Dimensions of Personalized and Precision Medicine

by Ernst R. Berndt

Author	: Ernst R. Berndt
Publisher	: University of Chicago Press
Total Pages	: 361
Release	: 2019-04-22
Genre	: Business & Economics
ISBN	: 022661123X

GET BOOK

Personalized and precision medicine (PPM)—the targeting of therapies according to an individual’s genetic, environmental, or lifestyle characteristics—is becoming an increasingly important approach in health care treatment and prevention. The advancement of PPM is a challenge in traditional clinical, reimbursement, and regulatory landscapes because it is costly to develop and introduces a wide range of scientific, clinical, ethical, and socioeconomic issues. PPM raises a multitude of economic issues, including how information on accurate diagnosis and treatment success will be disseminated and who will bear the cost; changes to physician training to incorporate genetics, probability and statistics, and economic considerations; questions about whether the benefits of PPM will be confined to developed countries or will diffuse to emerging economies with less developed health care systems; the effects of patient heterogeneity on cost-effectiveness analysis; and opportunities for PPM’s growth beyond treatment of acute illness, such as prevention and reversal of chronic conditions. This volume explores the intersection of the scientific, clinical, and economic factors affecting the development of PPM, including its effects on the drug pipeline, on reimbursement of PPM diagnostics and treatments, and on funding of the requisite underlying research; and it examines recent empirical applications of PPM.

Systems Analysis of Human Multigene Disorders

by Natalia Maltsev

Author	: Natalia Maltsev
Publisher	: Springer Science & Business Media
Total Pages	: 134
Release	: 2013-11-29
Genre	: Science
ISBN	: 1461487781

GET BOOK

Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.

Precision Medicine and Artificial Intelligence

by Michael Mahler

Author	: Michael Mahler
Publisher	: Academic Press
Total Pages	: 302
Release	: 2021-03-12
Genre	: Science
ISBN	: 032385432X

GET BOOK

Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. - Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions - Provides background, milestone and examples of precision medicine - Outlines the paradigm shift towards precision medicine driven by value-based systems - Discusses future applications of precision medicine research using AI - Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine

How Tobacco Smoke Causes Disease

by United States. Public Health Service. Office of the Surgeon General

Author	: United States. Public Health Service. Office of the Surgeon General
Publisher	:
Total Pages	: 728
Release	: 2010
Genre	: Government publications
ISBN	:

GET BOOK

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Tumor Organoids

by Shay Soker

Author	: Shay Soker
Publisher	: Humana Press
Total Pages	: 225
Release	: 2017-10-20
Genre	: Medical
ISBN	: 3319605119

GET BOOK

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Precision Medicine in Oncology

by Bulent Aydogan

Author	: Bulent Aydogan
Publisher	: John Wiley & Sons
Total Pages	: 288
Release	: 2020-11-02
Genre	: Medical
ISBN	: 1119432448

GET BOOK

A FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working – not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.

Beyond the HIPAA Privacy Rule

by Institute of Medicine

Author	: Institute of Medicine
Publisher	: National Academies Press
Total Pages	: 334
Release	: 2009-03-24
Genre	: Computers
ISBN	: 0309124999

GET BOOK

In the realm of health care, privacy protections are needed to preserve patients' dignity and prevent possible harms. Ten years ago, to address these concerns as well as set guidelines for ethical health research, Congress called for a set of federal standards now known as the HIPAA Privacy Rule. In its 2009 report, Beyond the HIPAA Privacy Rule: Enhancing Privacy, Improving Health Through Research, the Institute of Medicine's Committee on Health Research and the Privacy of Health Information concludes that the HIPAA Privacy Rule does not protect privacy as well as it should, and that it impedes important health research.

Targeted Therapies for Lung Cancer

by Ravi Salgia

Author	: Ravi Salgia
Publisher	: Springer
Total Pages	: 244
Release	: 2019-06-26
Genre	: Medical
ISBN	: 3030178323

GET BOOK

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.