Mechanisms of antibiotic resistance

Mechanisms of antibiotic resistance
Author: Jun Lin
Publisher: Frontiers Media SA
Total Pages: 226
Release: 2015-06-01
Genre: Antibiotics
ISBN: 2889195260

Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.

Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine

Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine
Author: National Academies Of Sciences Engineeri
Publisher: National Academies Press
Total Pages:
Release: 2022-07-20
Genre: Medical
ISBN: 9780309269452

The National Strategy for Combating Antibiotic Resistant Bacteria, published in 2014, sets out a plan for government work to mitigate the emergence and spread of resistant bacteria. Direction on the implementation of this strategy is provided in five-year national action plans, the first covering 2015 to 2020, and the second covering 2020 to 2025. Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine evaluates progress made against the national strategy. This report discusses ways to improve detection of resistant infections and estimate the risk to human health from environmental sources of resistance. In addition, the report considers the effect of agricultural practices on human and animal health and animal welfare and ways these practices could be improved, and advises on key drugs and diseases for which animal-specific test breakpoints are needed.

FDA Consumer

FDA Consumer
Author:
Publisher:
Total Pages: 252
Release: 2000
Genre: Consumer protection
ISBN:

Antibiotic Resistance

Antibiotic Resistance
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 496
Release: 2011-01-10
Genre: Medical
ISBN: 0309156114

Years of using, misusing, and overusing antibiotics and other antimicrobial drugs has led to the emergence of multidrug-resistant 'superbugs.' The IOM's Forum on Microbial Threats held a public workshop April 6-7 to discuss the nature and sources of drug-resistant pathogens, the implications for global health, and the strategies to lessen the current and future impact of these superbugs.

Superbug

Superbug
Author: Maryn McKenna
Publisher: Simon and Schuster
Total Pages: 290
Release: 2010-03-23
Genre: Medical
ISBN: 1439171831

LURKING in our homes, hospitals, schools, and farms is a terrifying pathogen that is evolving faster than the medical community can track it or drug developers can create antibiotics to quell it. That pathogen is MRSA—methicillin-resistant Staphyloccocus aureus—and Superbug is the first book to tell the story of its shocking spread and the alarming danger it poses to us all. Doctors long thought that MRSA was confined to hospitals and clinics, infecting almost exclusively those who were either already ill or old. But through remarkable reporting, including hundreds of interviews with the leading researchers and doctors tracking the deadly bacterium, acclaimed science journalist Maryn McKenna reveals the hidden history of MRSA’s relentless advance—how it has overwhelmed hospitals, assaulted families, and infiltrated agriculture and livestock, moving inexorably into the food chain. Taking readers into the medical centers where frustrated physicians must discard drug after drug as they struggle to keep patients alive, she discloses an explosion of cases that demonstrate how MRSA is growing more virulent, while evolving resistance to antibiotics with astonishing speed. It may infect us at any time, no matter how healthy we are; it is carried by a stunning number of our household pets; and it has been detected in food animals from cows to chickens to pigs. With the sensitivity of a novelist, McKenna portrays the emotional and financial devastation endured by MRSA’s victims, vividly describing the many stealthy ways in which the pathogen overtakes the body and the shock and grief of parents whose healthy children were felled by infection in just hours. Through dogged detective work, she discloses the unheard warnings that predicted the current crisis and lays bare the flaws that have allowed MRSA to rage out of control: misplaced government spending, inadequate public health surveillance, misguided agricultural practices, and vast overuse of the few precious drugs we have left. Empowering readers with the knowledge they need for self-defense, Superbug sounds an alarm: MRSA has evolved into a global emergency that touches almost every aspect of modern life. It is, as one deeply concerned researcher tells McKenna, "the biggest thing since AIDS."

Microbial Evolution and Co-Adaptation

Microbial Evolution and Co-Adaptation
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 330
Release: 2009-05-10
Genre: Science
ISBN: 0309131219

Dr. Joshua Lederberg - scientist, Nobel laureate, visionary thinker, and friend of the Forum on Microbial Threats - died on February 2, 2008. It was in his honor that the Institute of Medicine's Forum on Microbial Threats convened a public workshop on May 20-21, 2008, to examine Dr. Lederberg's scientific and policy contributions to the marketplace of ideas in the life sciences, medicine, and public policy. The resulting workshop summary, Microbial Evolution and Co-Adaptation, demonstrates the extent to which conceptual and technological developments have, within a few short years, advanced our collective understanding of the microbiome, microbial genetics, microbial communities, and microbe-host-environment interactions.

Hidden Dangers

Hidden Dangers
Author: Betsy Gunzelmann
Publisher: R&L Education
Total Pages: 145
Release: 2012
Genre: Education
ISBN: 1610485491

The Hidden Dangers in our schools have grown and intensified over the last few years; so much so that I was compelled to write a second edition to Hidden Dangers: Subtle Signs of Failing Schools. Our schools are complex places; each with its own unique climate, administration, faculty, students, parents and community members. Clearly, schools do not work in a vacuum; each is affected by the much larger society, government and economy. In this new edition we will be introduced to the interplay of these facets and how they can help and in some cases hinder our schools, our teachers, and our students from thriving. We also learn why it is more complicated now than ever, and the stakes are even higher than when Hidden Dangers was originally published back in 2008