Precision Molecular Pathology of Glioblastoma

by José Javier Otero
Precision Molecular Pathology of Glioblastoma
Author: José Javier Otero
Publisher: Springer Nature
Total Pages: 266
Release: 2021-04-30
Genre: Medical
ISBN: 3030691705
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This volume provides a balanced and realistic review of the current state of glioblastoma, ranging from traditional histological review, molecular pathology of glioma, modern radiomics, neurosurgical focus, and integration of treatment plans by neuro-oncologists. The book reviews basic principles such as epidemiology and etiology, and modern 2016 WHO classification of CNS tumors. Chapters cover a general overview of common molecular techniques used in molecular pathology, molecular pathology in a developing country, key drivers of patient outcomes and predictors of response to radiation and/or chemotherapy treatment, and immunohistochemical surrogates for key molecular pathology. It concludes with reviews on radiomics, animal and stem cell models of glioblastoma, and a chapter on the emerging field of Glioblastoma Neuroscience. Precision Molecular Pathology of Glioblastoma is intended for pathology residents and fellows interested in glioblastoma, general surgical pathologists who need reviews on how to implement modern glioblastoma classification, as well as neuro-radiologists, oncologists, and radiation oncologists needing a holistic perspective to glioblastoma diagnosis and management.

Molecular Neuropathology

by Gareth W. Roberts
Molecular Neuropathology
Author: Gareth W. Roberts
Publisher: Cambridge University Press
Total Pages: 204
Release: 1995-06-08
Genre: Medical
ISBN: 9780521425582
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This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using transgenic techniques and new therapeutic approaches. The volume is structured to illustrate all these approaches and demonstrate the practice and promise of molecular neuropathology.

Central Nervous System Tumours: Who Classification of Tumours

by WHO Classification of Tumours Editorial Board
Central Nervous System Tumours: Who Classification of Tumours
Author: WHO Classification of Tumours Editorial Board
Publisher: WHO Classification of Tumours
Total Pages: 584
Release: 2022-02-15
Genre: Medical
ISBN: 9789283245087
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****When not purchasing directly from the official sales agents of the WHO, especially at online bookshops, please note that there have been issues with counterfeited copies. Buy only from known sellers and if there are quality issues, please contact the seller for a refund.***** The WHO Classification of Tumours Central Nervous System Tumours is the sixth volume in the 5th edition of the WHO series on the classification of human tumors. This series (also known as the WHO Blue Books) is regarded as the gold standard for the diagnosis of tumors and comprises a unique synthesis of histopathological diagnosis with digital and molecular pathology. These authoritative and concise reference books provide indispensable international standards for anyone involved in the care of patients with cancer or in cancer research, underpinning individual patient treatment as well as research into all aspects of cancer causation, prevention, therapy, and education. What's new in this edition? The 5th edition, guided by the WHO Classification of Tumours Editorial Board, will establish a single coherent cancer classification presented across a collection of individual volumes organized on the basis of anatomical site (digestive system, breast, soft tissue and bone, etc.) and structured in a systematic manner, with each tumor type listed within a taxonomic classification: site, category, family (class), type, and subtype. In each volume, the entities are now listed from benign to malignant and are described under an updated set of headings, including histopathology, diagnostic molecular pathology, staging, and easy-to-read essential and desirable diagnostic criteria. Who should read this book? Pathologists Neuro-oncologists Neuroradiologists Medical oncologists Radiation oncologists Neurosurgeons Oncology nurses Cancer researchers Epidemiologists Cancer registrars This volume Prepared by 199 authors and editors Contributors from around the world More than 1100 high-quality images More than 3600 references WHO Classification of Tumours Online The content of this renowned classification series is now also available in a convenient digital format by purchasing a subscription directly from IARC here.

Etiology of Parkinson's Disease

by Jonas H. Ellenberg
Etiology of Parkinson's Disease
Author: Jonas H. Ellenberg
Publisher: CRC Press
Total Pages: 600
Release: 1995-03-01
Genre: Medical
ISBN: 9780824788230
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This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.

Neurodegeneration

by Dennis Dickson
Neurodegeneration
Author: Dennis Dickson
Publisher: John Wiley & Sons
Total Pages: 497
Release: 2011-11-07
Genre: Medical
ISBN: 1405196939
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Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

Neuropathology of Brain Tumors with Radiologic Correlates

by Meghana Chougule
Neuropathology of Brain Tumors with Radiologic Correlates
Author: Meghana Chougule
Publisher: Springer Nature
Total Pages: 361
Release: 2020-10-17
Genre: Medical
ISBN: 9811571260
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This highly illustrated book explores the pathological and radiological diagnosis of various brain tumors. Featuring nearly 500 high-quality colored images, it covers MR images, intra-operative squash cytology, histopathology and immunohistochemistry microphotographs of various brain and spine tumors, including differential diagnosis, as well as the molecular diagnosis and prognosis of each tumor. The book also presents case studies of typical and rare presentations, and introduces readers to a new procedure for intra-operative cytology: the modified fields stain, which stains the slide within 2 minutes, allowing quick, accurate reporting. This book uses concise text and a consistent point-wise format that makes reading and reviewing easy. The radiological and pathological correlates of brain and spine tumors serve as a ready-reference resource for residents, surgical and neuropathologists, neuroradiologists, neurosurgeons, neuro-oncologists and research scientists.

Neuropathology of Neurodegenerative Diseases

by Gabor G. Kovacs
Neuropathology of Neurodegenerative Diseases
Author: Gabor G. Kovacs
Publisher: Cambridge University Press
Total Pages: 320
Release: 2017-12-13
Genre: Medical
ISBN: 1316337650
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This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.

Diagnostic Pathology: Neuropathology E-Book

by B.K. Kleinschmidt-DeMasters
Diagnostic Pathology: Neuropathology E-Book
Author: B.K. Kleinschmidt-DeMasters
Publisher: Elsevier Health Sciences
Total Pages: 1035
Release: 2022-02-07
Genre: Medical
ISBN: 0323713319
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Covering all aspects of neuropathology, this updated volume in the Diagnostic Pathology series is an excellent point-of-care resource for pathologists at all levels of experience and training—both as a quick reference and as an efficient review to improve knowledge and skills. The third edition is an easy-to-use, one-stop reference for the most recent clinical, pathological, histological, and molecular knowledge in the field. It offers complete information on lesions of the brain, sellar region, and peripheral nerves, as well as benign cysts and selected infectious, inflammatory, reactive, vascular, and cortical dysplastic lesions, enabling you to arrive at the correct diagnosis and prepare actionable, useful reports. - Incorporates new WHO Classification of Tumors of the Central Nervous System, 5th Edition - Offers information on neoplasms of the brain, sellar region, and peripheral nerves, as well as benign cysts and selected infectious, inflammatory, reactive, and vascular lesions, aiding you in arriving at the correct diagnosis - Emphasizes surgical pathology but also provides significant content on nonneoplastic diseases that present with focal lesions, especially those that are potentially misinterpreted as neoplasms - Contains a detailed molecular diagnostics chapter with a section on methylation profiling, which has become indispensable as a method of tumor classification - Features new and updated chapters detailing several types of tumors that have been reclassified due to recent molecular driver information, cIMPACT-NOW recommendations, and the WHO Classification, 5th Edition

Molecular Neurology

by Stephen Waxman
Molecular Neurology
Author: Stephen Waxman
Publisher: Elsevier
Total Pages: 597
Release: 2010-07-26
Genre: Medical
ISBN: 0080546188
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Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology. - Describes the newest molecular aspects of neurological disorders - Provides an introduction to neurological disorders for basic scientists - Updates clinicians and clinical researchers on the most recent developments