Neuroendocrinology of Reproduction

Neuroendocrinology of Reproduction
Author: Norman T. Adler
Publisher: Springer Science & Business Media
Total Pages: 571
Release: 2012-12-06
Genre: Medical
ISBN: 1468438816

The subject of this book is neuroendocrinology, that branch of biological science devoted to the interactions between the two major integrative organ systems of animals-the endocrine and nervous systems. Although this science today reflects a fusion of endocrinology and neurobiology, this synthetic ap proach is relatively recent. At the beginning of the 20th century, when the British physiologists, Bayliss and Starling, first proposed endocrinology to be an independent field of inquiry, they went to great lengths to establish the autonomy of chemical secretions in general and their independence from nervous control in particular (Bayliss, W. M. , and Starling, E. H. , 1902, The mechanism of pancreatic secretion,]. Physiol. 28:325). They argued with Pav lov, who said that there was a strong influence of the nervous system on the gastrointestinal phenomena the endocrinologists were studying. For several decades, the English physiologists prevailed, at least in the West; and Pavlov's critique was not taken to heart by the practitioners of the newly emerging discipline of endocrinology. Through the work of Harris, the Scharrers, Sawyer, Everett, and others, there has been something of a scientific detente in the latter half of this century; the hybrid field of neuroendocrinology is now regarded as one of the corner stones of modern neural science and is of fundamental importance in basic and clinical endocrinology.

GnRH: The Master Molecule of Reproduction

GnRH: The Master Molecule of Reproduction
Author: Andrea C. Gore
Publisher: Springer Science & Business Media
Total Pages: 360
Release: 2002-04-30
Genre: Medical
ISBN: 9780792376811

Gonadotropin-releasing hormone (GnRH) cells are the key regulators of reproductive function in all vertebrate organisms. The GnRH molecule is synthesized in a small number of neurons in rostral hypothalamic regions of the brain. In mammals, these neurons release the GnRH decapeptide into the portal capillary system leading to the anterior pituitary gland. There, GnRH causes the release of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn act upon the gonads to stimulate their maturation, and to cause synthesis of sex steroid hormones, estrogen, progesterone and testosterone. Although each of the levels of the hypothalamic-pituitary-gonadal axis is critical for reproductive function, GnRH neurons play the primary role in the control of reproductive maturation and adult reproductive function, and may even play a role in reproductive senescence. Since its discovery in 1970, there has been intense interest in GnRH-producing neurons, with more than 8000 papers and chapters in the last decade alone. Despite this activity of research in basic and clinical science, there has never been a book written specifically on GnRH neurons. GnRH: The Master Molecule of Reproduction aims to bring together the large and diverse literature of both laboratory and applied research that focuses on these unique cells. This book will provide basic background into reproductive neuroendocrinology, as well as specifics regarding the role of GnRH neurons in the control of reproduction. Students studying endocrinology, reproduction, neuroendocrinology or molecular endocrinology will benefit from this book. In addition, this book will take a multi-species approach which will be useful both to basic researchers as well as clinicians. Whenever possible, species differences and similarities will be presented, and if possible, studies on humans, or the clinical relevance of basic research findings to humans will be discussed (such as the treatment of reproductive disorders such as abnormalities in pubertal development, or infertility).

Handbook of Neuroendocrinology

Handbook of Neuroendocrinology
Author: George Fink
Publisher: Academic Press
Total Pages: 895
Release: 2012
Genre: Medical
ISBN: 0123750970

Neuroendocrinology underpins fundamental physiological, molecular, biological, and genetic principles such as the regulation of gene transcription and translation. This handbook highlights the experimental and technical foundations of each area's major concepts and principles.

Clinical Neuroendocrinology

Clinical Neuroendocrinology
Author: Michael Wilkinson
Publisher: Cambridge University Press
Total Pages: 207
Release: 2019-01-03
Genre: Medical
ISBN: 1316645193

A concise and innovative account of clinical neuroendocrine disorders and the key principles underlying their diagnosis and management.

Speroff's Clinical Gynecologic Endocrinology and Infertility

Speroff's Clinical Gynecologic Endocrinology and Infertility
Author: Hugh S. Taylor
Publisher: Lippincott Williams & Wilkins
Total Pages: 3597
Release: 2019-07-11
Genre: Medical
ISBN: 1496350758

One of the world's most widely read gynecology texts for nearly 50 years, Speroff ’s Clinical Gynecologic Endocrinology and Infertility provides a complete explanation of the female endocrine system and offers practical guidance for evaluation and treatment of common disorders. In this fully revised ninth edition, the editorial and author team from Yale School of Medicine have assumed the reins of Dr. Speroff’s landmark work, retaining the clear, concise writing style and illustrations that clarify and explain complex concepts. This classic text remains indispensable for students, residents, and clinicians working in reproductive endocrinology and infertility, bringing readers up to date with recent advances that have occurred in this fast-changing field.

Neurobiology of Reproduction in the Female Rat

Neurobiology of Reproduction in the Female Rat
Author: John W. Everett
Publisher: Springer Science & Business Media
Total Pages: 222
Release: 2012-12-06
Genre: Medical
ISBN: 3642837972

It has been my privilege and pleasure during the past half century to participate in the unfolding of present-day concepts of the mammalian female reproductive cycles. When the studies recorded here began in the late 1930s it was already established that cyclic ovarian function is governed by gonadotropic secretions from the anterior pituitary gland, the "conductor of the endrocrine orchestra," and that in turn this activity is importantly dependent in some way upon secretion of estro gens and progesterone by the ovaries. Although a role of the nervous system was recognized for the reflex-like induction of ovulation in rabbits and cats and the in duction of pseudopregnancy in rats and mice, and although there was even some evidence of neural participation in ovulation in rats, a major central neural role in the female cycle of most species was not apparent. Gonadotropic fractions of pitui tary extracts having distinct follicle-stimulating and luteinizing activities in test ani mals had been obtained, and these respective effects had been fairly well charac terized. Prolactin was well known for its lactogenic activity, but its luteotropic role in rats and mice had yet to be revealed. The molecular structure of the several estro gens and progesterone was known, and they were readily available as synthetic pro ducts. The broad concept of ovarian-pituitary reciprocity appeared to be an accept able explanation of the female cycle, with the ovary in control through the rhythmic rise and fall in secretion of follicular estrogen.

Neuroendocrinology in Physiology and Medicine

Neuroendocrinology in Physiology and Medicine
Author: P. Michael Conn
Publisher: Springer Science & Business Media
Total Pages: 560
Release: 1999-10-06
Genre: Medical
ISBN: 1592597076

A panel of leading experts integrate the latest findings from basic and clinical science to create a comprehensive treatment of the processes by which the brain acts as an endocrine organ, not only to control hormonal functions, but also to maintain homeostasis and regulate behavior. The authors-recognized both as leaders in their fields and as skilled teachers-provide systematic coverage of the analytical, anatomical, functional, clinical, and pathological aspects of neuroendocrinology. Topics range from the interactions between the nervous and endocrine systems to the regulation of reproduction, development, metabolism, fluid balance, and biological rhythms. Neuroendocrinology in Physiology and Medicine offers an unprecedented marriage of clinical and basic knowledge that has been missing from classical neuroscience, endocrinology, and physiology texts. It will teach today's medical students and serve researchers as a valuable reference to this rapidly growing field.

Hormones and Reproduction in Fishes, Amphibians, and Reptiles

Hormones and Reproduction in Fishes, Amphibians, and Reptiles
Author: David O. Norris
Publisher: Springer Science & Business Media
Total Pages: 627
Release: 2012-12-06
Genre: Science
ISBN: 1461318696

Comparative endocrinology is one of the most rapidly developing subdis ciplines within the field of endocrinology, and it is having a significant impact on research at the molecular, cellular, organisma1 and environmental levels. Much of the current ferment in endocrinology is in reproductive endocrinology. The purpose of this volume on hormones and reproduction in fishes, amphibians and reptiles is to summarize our present understandings and to identify important research problems to be addressed in the area of comparative reproductive endocrinology. It was inspired by the gathering at Copper Mountain, Colorado, of eminent endocrine scientists from around the world on the occasion of the Tenth International Symposium on Comparative Endocrinology in July, 1985. While preparing for that meeting, we decided that a special volume on reproductive endocrinology was needed to summarize what is known and to stimulate research in particular directions. Why do we emphasize fishes, amphibians and reptiles? First, knowledge about the reproductive endocrinology of these ectothermic vertebrates can provide a clearer picture of the evolution of reproductive hormones and their effects on target organs. This comparative approach can lead to new theories about the evolution of reproductive control mechanisms. Second, studies concerning the reproductive endocrinology of "lower" vertebrates can result in development of "model systems" for application to studies of birds and mammals. Indeed, information about the patterns of reproductive control in ectothermic vertebrates can tell us which are evolutionarily stable and which are labile.