Next Generation Antidepressants

Next Generation Antidepressants
Author: Chad E. Beyer
Publisher: Cambridge University Press
Total Pages: 151
Release: 2010-05-20
Genre: Medical
ISBN: 1139833030

The World Health Organization defines depression as a primary contributor to the global burden of disease and predicts it will become the second leading cause of death by 2020. The need to develop effective therapies has never been so pressing. Current antidepressant drugs have several limitations. This 2010 book looks at the future of mood-disorder research, covering the identification of new therapeutic targets, establishing new preclinical models, new medicinal chemistry opportunities, and fostering greater understanding of genetic influences. These strategies are likely to help build a better picture of the disease process, and lead to new opportunities for patient stratification and treatment. The ultimate goal for this strand of research is to develop more personalized and effective treatments for this chronic and debilitating condition. This is essential reading for all those involved in psychopharmacologic drug development, and mental health clinicians seeking a preview of discoveries soon to influence their practice.

Next Generation Antidepressants

Next Generation Antidepressants
Author: Chad E. Beyer
Publisher: Cambridge University Press
Total Pages: 151
Release: 2010-05-20
Genre: Medical
ISBN: 0521760585

The future of mood-disorder research: covering identification of new therapeutic targets, preclinical models, and medicinal chemistry opportunities.

Rapid Acting Antidepressants

Rapid Acting Antidepressants
Author:
Publisher: Academic Press
Total Pages: 404
Release: 2020-06-29
Genre: Medical
ISBN: 0128201908

The Advances in Pharmacology series presents a variety of chapters from the best authors in the field. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

Ketamine for Treatment-Resistant Depression

Ketamine for Treatment-Resistant Depression
Author: Gustavo H. Vazquez
Publisher: Academic Press
Total Pages: 170
Release: 2020-09-16
Genre: Medical
ISBN: 0128210346

Ketamine for Treatment-Resistant Depression: Neurobiology and Applications provides a simple, evidence-based overview for neuropsychiatrists and translational researchers on this medication, its mechanisms of actions, eligibility of patients for treatment, and the preparation and implementation of ketamine clinics. - Provides efficacy research on ketamine as a treatment for depression - Identifies best practices for clinical use, both long-term and acute - Discusses the molecular mechanisms and neurobiology of action

Better Than Prozac

Better Than Prozac
Author: Samuel H. Barondes
Publisher: Oxford University Press
Total Pages: 234
Release: 2005-01-14
Genre: Health & Fitness
ISBN: 019517979X

Every day millions of people take psychiatric drugs. In Better Than Prozac Samuel Barondes considers the benefits and limitations of Prozac, Ritalin, Valium, Risperdal, and other widely used medications and the ways that superior ones are being created. In tracing the early history of these drugs Barondes describes the accidental observations that led to their discovery and their great impact on our view of mental illness. He goes on to show how their unexpected therapeutic effects were attributed to their influence on neurotransmitters that carry signals in the brain and how this guided their improvement. But Barondes reminds us that, like the originals, current psychiatric drugs don't always work, and often have negative side effects. Furthermore, none were crafted as remedies for known brain abnormalities. In contrast, the design of the drugs of the future will be based on a different approach: an understanding of the molecular mechanisms that give rise to specific patterns of mental symptoms. Using colorful examples of contemporary research, he shows how it is gradually leading to a new generation of psychiatric medications. A lucid evaluation of psychopharmacology, Better Than Prozac offers a deep understanding of psychiatric drugs for people who take them, those who are considering them, and those who are just fascinated by the powerful effects of these simple chemicals on our thoughts and our feelings.

Fluoxetine

Fluoxetine
Author: Graziano Pinna
Publisher:
Total Pages: 412
Release: 2015-04-01
Genre:
ISBN: 9781634820769

Fluoxetine, best known by the trade name ProzacĀ®, unlike other psychotropic drugs whose effects were serendipitously stumbled upon, was the first developed for a precise mechanism of action, that is, the ability to selectively inhibit serotonin reuptake, based upon the theory that increasing the availability of serotonin would treat major depression. Once approved by the FDA in 1987, fluoxetine quickly became the most prescribed psychotropic drug worldwide and its success in improving mood disorders has triggered the development of a large number of congener molecules, commonly known as SSRIs after their purported mechanism of action. However, a quarter of a century after its development, the idea that fluoxetine asserts its positive behavioral effect through inhibition of serotonergic reuptake is not firmly established. This book reviews several preclinical and clinical reports suggesting that the pharmacological effects of fluoxetine may be mediated by means other than the regulation of serotonin, including the regulation of gene expression, modifying epigenetic mechanisms as well as modifying microRNAs. One of the most prominent mechanisms for the therapeutic relevance of fluoxetine relates to influencing neuroplasticity by enhancing neurotropic factors, including BDNF signaling and altering adult neurogenesis. The ability of fluoxetine to rapidly increase neurosteroid levels accounts for the fast anxiolytic effects of this drug. Fluoxetine action at sigma-1 receptor or modulating glutamatergic neurotransmission as well as the combination of fluoxetine with other psychotropic drugs is discussed in relation to its therapeutic effects. While fluoxetine was primarily prescribed as an antidepressant, this drug currently represents a treatment of choice for a broad spectrum of psychiatric disorders, including post-traumatic stress disorder and a range of anxiety disorders. This drug even possesses analgesic actions and is a valuable therapy for stroke. This book also highlights emerging evidence on the gender-specific effects of fluoxetine, its potential adverse features, including its addiction liability in combination with psychostimulants, and the impact of perinatal fluoxetine exposure.

Clinical Psychopharmacology

Clinical Psychopharmacology
Author: S. Nassir Ghaemi
Publisher: Oxford University Press
Total Pages: 601
Release: 2018-12-05
Genre: Medical
ISBN: 0199995508

Clinical Psychopharmacology offers a comprehensive guide to clinical practice that explores two major aspects of the field: the clinical research that exists to guide clinical practice of psychopharmacology, and the application of that knowledge with attention to the individualized aspects of clinical practice. The text consists of 50 chapters, organized into 6 sections, focusing on disease-modifying effects, non-DSM diagnostic concepts, and essential facts about the most common drugs. This innovative book advocates a scientific and humanistic approach to practice and examines not only the benefits, but also the harms of drugs. Providing a solid foundation of knowledge and a great deal of practical information, this book is a valuable resource for practicing psychiatrists, psychiatric nurse practitioners, medical students and trainees in psychiatry, as well as pharmacists.

Lippincott's Primary Care Psychiatry

Lippincott's Primary Care Psychiatry
Author: Robert M. McCarron
Publisher: Lippincott Williams & Wilkins
Total Pages: 352
Release: 2012-03-28
Genre: Medical
ISBN: 1451152876

This book helps family practitioners, internists, nurse practitioners, physician assistants, and mental health practitioners understand, diagnose, and effectively treat the most common psychiatric problems seen in the primary care office setting. The introductory chapter addresses the primary care psychiatric interview. Subsequent chapters cover specific disorders and follow a consistent format: Introductory Case; Clinical Highlights; Clinical Significance; Diagnosis; Differential Diagnosis, including "Not to Be Missed" points; Biopsychosocial Treatment, including "When to Refer"; Practice Pointers case studies; ICD-9 codes; and Practical Resources. Appendices include time-saving strategies and medication tables. An anatomical wall chart for the office is also included. A companion Website includes fully searchable text and patient handouts for various psychiatric disorders.

Drug-Induced Liver Injury

Drug-Induced Liver Injury
Author:
Publisher: Academic Press
Total Pages: 290
Release: 2019-07-13
Genre: Medical
ISBN: 0128173173

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series