Origins of Inbred Mice

Origins of Inbred Mice
Author: Herbert C. III Morse
Publisher: Elsevier
Total Pages: 737
Release: 2012-12-02
Genre: Nature
ISBN: 0323142834

Origins of Inbred Mice documents the proceedings of a symposium on the state of knowledge on inbred mice held in Bethesda, Maryland, in 1978. The book is organized into seven parts. Part I provides introductory remarks on the history of the development of inbred mice. Part II contains papers that examine mutations of inbred strains of mice. Part III contains studies dealing with viruses that affect inbred mice, including those that cause leukemia and mammary tumors. Part IV examines histocompatibility genes and their antigens; cell surface antigens of mouse leukemia; the characteristics of genes of the Tla region of the mouse; and the use of recombinant inbred strains in gene mapping. Part V presents studies on differences among sublines of inbred mouse strains. The papers in Part VI focus on wild mice, covering their classification and biochemical polymorphisms. Finally, Part VIII discusses the viruses, T locus, and histocompatibility antigens of wild mice.

Making Mice

Making Mice
Author: Karen Rader
Publisher: Princeton University Press
Total Pages: 326
Release: 2004-03-21
Genre: Science
ISBN: 9780691016368

Making Mice blends scientific biography, institutional history, and cultural history to show how genetically standardized mice came to play a central role in contemporary American biomedical research. Karen Rader introduces us to mouse "fanciers" who bred mice for different characteristics, to scientific entrepreneurs like geneticist C. C. Little, and to the emerging structures of modern biomedical research centered around the National Institutes of Health. Throughout Making Mice, Rader explains how the story of mouse research illuminates our understanding of key issues in the history of science such as the role of model organisms in furthering scientific thought. Ultimately, genetically standardized mice became icons of standardization in biomedicine by successfully negotiating the tension between the natural and the man-made in experimental practice. This book will become a landmark work for its understanding of the cultural and institutional origins of modern biomedical research. It will appeal not only to historians of science but also to biologists and medical researchers.

Mouse Genetics

Mouse Genetics
Author: Professor of Molecular Biology Lee M Silver, Professor Dr
Publisher: Oxford University Press on Demand
Total Pages: 362
Release: 1995
Genre: Medical
ISBN: 9780195075540

Mouse Genetics offers for the first time in a single comprehensive volume a practical guide to mouse breeding and genetics. Nearly all human genes are present in the mouse genome, making it an ideal organism for genetic analyses of both normal and abnormal aspects of human biology. Written as a convenient reference, this book provides a complete description of the laboratory mouse, the tools used in analysis, and procedures for carrying out genetic studies, along with background material and statistical information for use in ongoing data analysis. It thus serves two purposes, first to provide students with an introduction to the mouse as a model system for genetic analysis, and to give practicing scientists a detailed guide for performing breeding studies and interpreting experimental results. All topics are developed completely, with full explanations of critical concepts in genetics and molecular biology. As investigators around the world are rediscovering both the heuristic and practical value of the mouse genome, the demand for a succinct introduction to the subject has never been greater. Mouse Genetics is intended to meet the needs of this wide audience.

The Laboratory Mouse

The Laboratory Mouse
Author: Hans Hedrich
Publisher: Academic Press
Total Pages: 869
Release: 2012-06-14
Genre: Science
ISBN: 012382009X

The Laboratory Mouse, Second Edition is a comprehensive book written by international experts. With inclusions of the newly revised European standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. This well-illustrated edition offers new and updated chapters including immunology, viruses and parasites, behavior, enrichment and care standards of laboratory mice across the life sciences, medical and veterinary fields. - Features four-color illustrations with complete instruction on mouse surgery, anatomy, behavior and care of the mouse in laboratory research - Offers additional chapters on new mouse strains, phenotyping of strains, bacteria and parasites, and immunology - Includes the newly revised EU standards on care, as well as, comparisons to standards and regulations in the US and other countries

The Laboratory Rat

The Laboratory Rat
Author: Henry J. Baker
Publisher: Elsevier
Total Pages: 450
Release: 2013-10-02
Genre: Medical
ISBN: 1483268616

The Laboratory Rat, Volume I: Biology and Diseases focuses on the use of rats in specific areas of research, ranging from dental research to toxicology. The first part of this book retraces the biomedical history of early events and personalities involved in the establishment of rats as a leading laboratory animal. The taxonomy, genetics and inbred strains of rats are also elaborated. The next chapters illustrate the hematology, clinical biochemistry, and anatomical and physiological features of the laboratory rat. This text concludes with a description of infectious diseases that may be contracted from laboratory and/or wild rats. This volume is a good source for commercial and institutional organizations involved in producing rats for research use, specialists in laboratory animal, animal care and research technicians, as well as students in graduate and professional curricula.

Nutrient Requirements of Laboratory Animals,

Nutrient Requirements of Laboratory Animals,
Author: National Research Council
Publisher: National Academies Press
Total Pages: 188
Release: 1995-02-01
Genre: Science
ISBN: 0309051266

In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparationâ€"including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.

Mammalian Genetics

Mammalian Genetics
Author: William Ernest Castle
Publisher:
Total Pages: 232
Release: 1940
Genre: Science
ISBN:

Heredity in general; Mendelian inheritance; Modified mendelian ratios; Linkage, as illustrated in the study of rabbit genes; Known genes of rodents other than the rabbit; Hybridization and hybrid vigor; Self-sterility; Bipolar sexuality; Sex differentiation; Sex determination; Sex-linked inheritance in drosophila and in mammals; Inheritance of blood groups in man and rabbit; Dominance; Multiple alleles; Lethal genes; Balanced lethals; Genes having pathological effects - "sublethal" genes; Maternal inheritance; The inheritance of body size; Variation and selection; Quantitative characters; Pure lines; Major contributions of fish genetics; The more important gene mutations of domestic mammals.

The Laboratory Mouse

The Laboratory Mouse
Author: Clyde Edgar Keeler
Publisher:
Total Pages: 81
Release: 1931
Genre: Mice
ISBN: 9780674336513