Practical Medicinal Chemistry with Macrocycles

by Eric Marsault

Author	: Eric Marsault
Publisher	: John Wiley & Sons
Total Pages	: 617
Release	: 2017-09-12
Genre	: Science
ISBN	: 1119092566

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Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations

The Practice of Medicinal Chemistry

by Camille Georges Wermuth

Author	: Camille Georges Wermuth
Publisher	: Elsevier
Total Pages	: 903
Release	: 2015-07-01
Genre	: Science
ISBN	: 012417213X

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The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery.With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. - Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field - Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts - Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research - An image bank is available for instructors at www.textbooks.elsevier.com

Progress in Medicinal Chemistry

by

Author	:
Publisher	: Elsevier
Total Pages	: 368
Release	: 2018-04-09
Genre	: Medical
ISBN	: 0444641440

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Progress in Medicinal Chemistry, Volume 57, provides a review of eclectic developments in medicinal chemistry, with this volume including chapters on the CaSR field, CFTR modulators in cystic fibrosis, macrocycles, VMAT2 inhibitors, and Big Data in Drug Discovery. - Provides extended, timely reviews of topics in medicinal chemistry - Contains targets and technologies relevant to the discovery of tomorrow's drugs - Presents analyses of successful drug discovery programs

Medicinal Chemistry for Practitioners

by Jie Jack Li

Author	: Jie Jack Li
Publisher	: John Wiley & Sons
Total Pages	: 416
Release	: 2020-06-23
Genre	: Medical
ISBN	: 1119607280

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Presenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful reference for veteran drug hunters, this book summarizes the state-of-the-art of medicinal chemistry. It covers key drug targets including enzymes, receptors, and ion channels, and hit and lead discovery. The book hen surveys a drug's pharmacokinetics and toxicity, with a solid chapter covering fundamental bioisosteres as a guide to structure-activity relationship investigations.

Heterocycles

by Teresa M. V. D. Pinho e Melo

Author	: Teresa M. V. D. Pinho e Melo
Publisher	: John Wiley & Sons
Total Pages	: 564
Release	: 2022-06-20
Genre	: Science
ISBN	: 3527348867

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Heterocycles A must-read handbook on heterocycle chemistry with a focus on sustainability Heterocycles feature prominently in our daily life—they are essential for pharmaceuticals, agrochemicals, and fine chemicals. More, numerous natural, bioactive products contain heterocyclic compounds. As a result, heterocyclic chemistry continues to be one of the most important areas of study in organic chemistry. Heterocycles provides an important reference on a wide range of topics relating to heterocyclic chemistry, with a heavy emphasis on sustainable methods and greener syntheses. The book describes state-of-the-art synthetic methods, such as photochemical reactions, dearomatization reactions, organocatalysis, transition metal catalysis, and biocatalysis. It also covers: Sustainable methods, like flow chemistry, mechanochemistry, and multicomponent synthesis Strategies for the synthesis of heterocyclic macrocycles and medium-sized rings Characterization of heterocyclic compounds Heterocycles is a useful reference for organic chemists, natural products chemists, catalytic chemists, and medicinal chemists in academia and industry.

Macrocycles in Drug Discovery

by Jeremy I Levin

Author	: Jeremy I Levin
Publisher	: Royal Society of Chemistry
Total Pages	: 526
Release	: 2015
Genre	: Medical
ISBN	: 1849737010

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This series provides a comprehensive resource for postgraduate students and for scientists in academia or industry wanting to learn topics outside their own areas of expertise.

Small Molecule Medicinal Chemistry

by Werngard Czechtizky

Author	: Werngard Czechtizky
Publisher	: John Wiley & Sons
Total Pages	: 528
Release	: 2015-09-21
Genre	: Science
ISBN	: 1118771575

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Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Chapters discuss benefits, challenges, case studies, and industry perspectives for improving drug discovery programs with respect to quality and costs. • Focuses on small molecules and their critical role in medicinal chemistry, reviewing chemical and economic advantages, challenges, and trends in the field from industry perspectives • Discusses novel approaches and key topics, like screening collection enhancement, risk sharing, HTS triage, new lead finding approaches, diversity-oriented synthesis, peptidomimetics, natural products, and high throughput medicinal chemistry approaches • Explains how to reduce design-make-test cycle times by integrating medicinal chemistry, physical chemistry, and ADME profiling techniques • Includes descriptive case studies, examples, and applications to illustrate new technologies and provide step-by-step explanations to enable them in a laboratory setting

Advances in Heterocyclic Chemistry

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Author	:
Publisher	: Academic Press
Total Pages	: 440
Release	: 2019-03-19
Genre	: Science
ISBN	: 0128174749

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Advances in Heterocyclic Chemistry, Volume 129 is the definitive series in the field—one of great importance to organic chemists, polymer chemists and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive, updated release includes chapters on Metal-Catalyzed Direct Arylation of 1,2-Azoles, The Literature of Heterocyclic Chemistry, Part XVII, 2017, Pyrrolo-, Imidazoquinolines and Pyrroloquinazolines with a Bridgehead Nitrogen, Synthesis and Reactions of Arsole, Stibole, and Bismole, Advances in Synthesis and Chemistry of Aziridines, and more. - Considered the definitive serial in the field of heterocyclic chemistry - Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists - Provides the latest comprehensive reviews written by established authorities in the field - Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds

Inhibitors of Protein–Protein Interactions

by Ali Tavassoli

Author	: Ali Tavassoli
Publisher	: Royal Society of Chemistry
Total Pages	: 357
Release	: 2020-12-07
Genre	: Science
ISBN	: 178801569X

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Protein-protein interactions (PPI) are at the heart of the majority of cellular processes, and are frequently dysregulated or usurped in disease. Given this central role, the inhibition of PPIs has been of significant interest as a means of treating a wide variety of diseases. However, there are inherent challenges in developing molecules capable of disrupting the relatively featureless and large interfacial areas involved. Despite this, there have been a number of successes in this field in recent years using both traditional drug discovery approaches and innovative, interdisciplinary strategies using novel chemical scaffolds. This book comprehensively covers the various aspects of PPI inhibition, encompassing small molecules, peptidomimetics, cyclic peptides, stapled peptides and macrocycles. Illustrated throughout with successful case studies, this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.