Precision Medicine in Cardiovascular Disease Prevention

by Seth S. Martin

Author	: Seth S. Martin
Publisher	: Springer Nature
Total Pages	: 194
Release	: 2021-07-07
Genre	: Medical
ISBN	: 3030750558

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This book contains the current knowledge and potential future developments of precision medicine techniques including artificial intelligence, big data, mobile health, digital health and genetic medicine in the prevention of cardiovascular disease. It reviews the presently used advanced precision medicine techniques and fundamental principles that continue to act as guiding forces for many medical professionals in applying precision and preventative medical techniques in their day-to-day practices. Precision Medicine in Cardiovascular Disease Prevention describes current knowledge and potential future developments in this rapidly expanding field. It therefore provides a valuable resource for all practicing and trainee cardiologists looking to develop their knowledge and integrate precision medicine techniques into their practices.

Sex-Specific Analysis of Cardiovascular Function

by Peter L. M. Kerkhof

Author	: Peter L. M. Kerkhof
Publisher	: Springer
Total Pages	: 734
Release	: 2018-07-26
Genre	: Medical
ISBN	: 331977932X

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This book gathers together contributions from internationally renowned authors in the field of cardiovascular systems and provides crucial insight into the importance of sex- and gender-concepts during the analysis of patient data. This innovative title is the first to offer the elements necessary to consider sex-related properties in both clinical and basic studies regarding the heart and circulation on multiscale levels (i.e. molecular, cellular, electrophysiologically, neuroendocrine, immunoregulatory, organ, allometric, and modeling). Observed differences at (ultra)cellular and organ level are quantified, with focus on clinical relevance and implications for diagnosis and patient management. Since the cardiovascular system is of vital importance for all tissues, Sex-Specific Analysis of Cardiovascular Function is an essential source of information for clinicians, biologists, and biomedical investigators. The wide spectrum of differences described in this book will also act as an eye-opener and serve as a handbook for students, teachers, scientists and practitioners.

Genetics of Cardiovascular Disease

by

Author	:
Publisher	: Academic Press
Total Pages	: 0
Release	: 2014-04-22
Genre	: Science
ISBN	: 9780123869302

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This volume of the esteemed Progress in Molecular Biology and Translational Science series focuses on cutting-edge research related to the genetics of cardiovascular disease. Written by top experts in the field, this volume covers a range of topics, including: Genetic models of atherosclerosis MicroRNAs in cardiovascular disease The role of the transcription factor KLF2 in vascular development and disease Zebrafish as models of cardiovascular disease and hematopoietic development Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references.

Economic Dimensions of Personalized and Precision Medicine

by Ernst R. Berndt

Author	: Ernst R. Berndt
Publisher	: University of Chicago Press
Total Pages	: 361
Release	: 2019-04-22
Genre	: Business & Economics
ISBN	: 022661123X

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Personalized and precision medicine (PPM)—the targeting of therapies according to an individual’s genetic, environmental, or lifestyle characteristics—is becoming an increasingly important approach in health care treatment and prevention. The advancement of PPM is a challenge in traditional clinical, reimbursement, and regulatory landscapes because it is costly to develop and introduces a wide range of scientific, clinical, ethical, and socioeconomic issues. PPM raises a multitude of economic issues, including how information on accurate diagnosis and treatment success will be disseminated and who will bear the cost; changes to physician training to incorporate genetics, probability and statistics, and economic considerations; questions about whether the benefits of PPM will be confined to developed countries or will diffuse to emerging economies with less developed health care systems; the effects of patient heterogeneity on cost-effectiveness analysis; and opportunities for PPM’s growth beyond treatment of acute illness, such as prevention and reversal of chronic conditions. This volume explores the intersection of the scientific, clinical, and economic factors affecting the development of PPM, including its effects on the drug pipeline, on reimbursement of PPM diagnostics and treatments, and on funding of the requisite underlying research; and it examines recent empirical applications of PPM.

Toward Precision Medicine

by National Research Council

Author	: National Research Council
Publisher	: National Academies Press
Total Pages	: 142
Release	: 2012-01-16
Genre	: Medical
ISBN	: 0309222222

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Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Genomic and Precision Medicine

by Geoffrey S. Ginsburg

Author	: Geoffrey S. Ginsburg
Publisher	: Academic Press
Total Pages	: 379
Release	: 2022-04-09
Genre	: Science
ISBN	: 0128006536

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Genomic and Precision Medicine: Oncology, Third Edition focuses on the applications of genome discovery as research points to personalized cancer therapies. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. - Provides a comprehensive volume written and edited by oncology genomic specialists for oncology health providers - Includes succinct commentary and key learning points that will assist providers with their local needs for implementation of genomic and personalized medicine into practice - Presents an up-to-date overview on major opportunities for genomic and personalized medicine in practice - Covers case studies that highlight the practical use of genomics in the management of patients

Essentials of Genomic and Personalized Medicine

by Geoffrey S. Ginsburg

Author	: Geoffrey S. Ginsburg
Publisher	: Academic Press
Total Pages	: 851
Release	: 2009-10-02
Genre	: Science
ISBN	: 0080958117

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Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, Essentials of Genomic and Personalized Medicine will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine. - Full color throughout - Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field - Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practic - Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science

Molecular Cardiology

by Zhongjie Sun

Author	: Zhongjie Sun
Publisher	: Springer Science & Business Media
Total Pages	: 410
Release	: 2008-02-01
Genre	: Medical
ISBN	: 159259879X

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The aim of Molecular Cardiology: Methods and Protocols is to document state-of-the-art molecular and genetic techniques in the area of cardiology. These modern approaches enable researchers to readily study heart diseases at the molecular level and will promote the development of new therapeutic str- egies. Methods for genetic dissection, signal transduction, and microarray analysis are excellent tools for the study of the molecular mechanisms of cardiovascular diseases. Protocols for transgenesis take advantage of recent advances in many areas of molecular and cell biology. Transgenic models of heart diseases (cardiac hypertrophy, cardiac dysfunction, and so on. ) are powerful tools for the study of heart disease pathogenesis. Methods for gene transfer to heart tissue using viral and nonviral vectors form the basis of gene therapy for heart diseases. Heart-specific promoters containing a hypox- inducible cardioprotective gene switch are key for protection of the heart from ischemia. Gene and stem cell therapies open novel and exciting avenues for the prevention and treatment of heart diseases. Molecular Cardiology: Methods and Protocols consists of 26 chapters de- ing with various aspects of molecular cardiology, including gene transfer and gene therapy for cardiovascular disease, stem cell therapy for cardiovascular disease, gene analysis in the injured and hypertrophied heart, and transgenesis in cardiovascular research. This book provides step-by-step methods for the successful completion of experimental procedures, and would be useful for both experienced and new investigators in the field of molecular cardiology.

Machine Learning in Cardiovascular Medicine

by Subhi J. Al'Aref, M.D.

Author	: Subhi J. Al'Aref, M.D.
Publisher	: Academic Press
Total Pages	: 454
Release	: 2020-12-11
Genre	: Medical
ISBN	: 0128202734

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Machine Learning in Cardiovascular Medicine addresses the ever-expanding applications of artificial intelligence (AI), specifically machine learning (ML), in healthcare and within cardiovascular medicine. The book focuses on emphasizing ML for biomedical applications and provides a comprehensive summary of the past and present of AI, basics of ML, and clinical applications of ML within cardiovascular medicine for predictive analytics and precision medicine. It helps readers understand how ML works along with its limitations and strengths, such that they can could harness its computational power to streamline workflow and improve patient care. It is suitable for both clinicians and engineers; providing a template for clinicians to understand areas of application of machine learning within cardiovascular research; and assist computer scientists and engineers in evaluating current and future impact of machine learning on cardiovascular medicine. Provides an overview of machine learning, both for a clinical and engineering audience Summarize recent advances in both cardiovascular medicine and artificial intelligence Discusses the advantages of using machine learning for outcomes research and image processing Addresses the ever-expanding application of this novel technology and discusses some of the unique challenges associated with such an approach