Since the spread of COVID-19, conferences have been canceled, schools have closed, and libraries around the world are facing difficult decisions on which services to offer and how, ranging from minimal restrictions to full closures. Depending on the country, state, or city, a government may have a different approach, sometimes ordering the closure of all institutions, others indicating that it’s business as usual, and others simply leaving decisions up to library directors. All libraries worldwide have been affected, from university libraries to public library systems and national libraries. Throughout these closures, libraries continue to provide services to their communities, which has led to an emerging area of research on library services, new emerging technologies, and the advancements made to libraries during this global health crisis. The Handbook of Research on Library Response to the COVID-19 Pandemic consists of chapters that contain essential library services and emerging research and technology that evolved and/or has continued during the COVID-19 pandemic, as well as the challenges and opportunities that have been undertaken as a result. The chapters provide in-depth research, surveys, and information on areas such as remote working, machine learning, data management, and the role of information during COVID-19. This book is a valuable reference tool for practitioners, stakeholders, researchers, academicians, and students who are interested in the current state of libraries during a pandemic and the future outlook.