Principles and Practice of Stereotactic Radiosurgery

Principles and Practice of Stereotactic Radiosurgery
Author: Lawrence S. Chin
Publisher: Springer
Total Pages: 825
Release: 2015-01-05
Genre: Medical
ISBN: 1461483638

Principles and Practice of Stereotactic Radiosurgery, Second Edition serves as the definitive reference textbook for SRS practitioners. It provides a theoretical basis for the use of therapeutic radiation including imaging techniques and radiobiology. The bulk of the textbook contains chapters that are comprehensive in scope on all diseases that are treated by SRS. Lastly, it addresses administrative and technical aspects of running an SRS unit. Each chapter provides an expansive treatment of the subject, with emphasis placed on the technical aspects of SRS so that practitioners in this field can use it as a daily reference. Written by noted experts in the field, Principles and Practice of Stereotactic Radiosurgery, Second Edition is the only reference needed for neurosurgeons, radiation oncologists and medical physicists at all levels of training and practice who are interested in SRS.

Handbook of Evidence-Based Radiation Oncology

Handbook of Evidence-Based Radiation Oncology
Author: Eric K. Hansen
Publisher: Springer
Total Pages: 946
Release: 2018-05-07
Genre: Medical
ISBN: 3319626426

The Third Edition of Handbook of Evidence-Based Radiation Oncology updates and revises the previous successful editions and serves as a key reference for radiation oncology professionals. Organized by body site, concise clinical chapters provide easy access to critical information. Important "pearls" of epidemiology, anatomy, pathology, and clinical presentation are highlighted. The key elements of the work-up are listed, followed by staging and/or risk classification systems. Treatment recommendations are discussed based on stage, histology, and/or risk classification. Brief summaries of key trials and studies provide the rationale for the recommendations. Practical guidelines for radiation techniques are described and complications and follow-up guidelines are outlined. The Third Edition incorporates new key studies and trials to reflect current radiation oncology practice; includes the most recent staging systems; and features new color illustrations and anatomic atlases to aid in treatment planning. This book is a valuable resource for students, resident physicians, fellows, and other practitioners of radiation oncology.

Essentials of Clinical Radiation Oncology

Essentials of Clinical Radiation Oncology
Author: Matthew C. Ward, MD
Publisher: Springer Publishing Company
Total Pages: 671
Release: 2017-12-28
Genre: Medical
ISBN: 0826168558

Essentials of Clinical Radiation Oncology is a comprehensive, user-friendly clinical review that summarizes up-to-date cancer care in an easy-to-read format. Each chapter is structured for straightforward navigability and information retention beginning with a “quick-hit” summary that contains an overview of each disease, its natural history, and general treatment options. Following each "quick-hit" are high-yield summaries covering epidemiology, risk factors, anatomy, pathology, genetics, screening, clinical presentation, workup, prognostic factors, staging, treatment paradigms, and medical management for each malignancy. Each treatment paradigm section describes the current standard of care for radiation therapy including indications, dose constraints, and side effects. Chapters conclude with an evidence-based question and answer section which summarizes practice-changing data to answer key information associated with radiation treatment outcomes. Flow diagrams and tables consolidate information throughout the book that all radiation oncologists and related practitioners will find extremely useful when approaching treatment planning and clinical care. Essentials of Clinical Radiation Oncology has been designed to replicate a "house manual" created and used by residents in training and is a "one-stop" resource for practicing radiation oncologists, related practitioners, and radiation oncology residents entering the field. Key Features: Offers digestible information as a learning guide for general practice Examines essential clinical questions which are answered with evidence-based data from important clinical studies Places clinical trials and data into historical context and points out relevance in current practice Provides quick reference tables on treatment options and patient selection, workup, and prognostic factors by disease site

Inhibiting PARP as a Strategic Target in Cancer

Inhibiting PARP as a Strategic Target in Cancer
Author: Christina Annunziata
Publisher: Frontiers Media SA
Total Pages: 99
Release: 2016-08-05
Genre: Medicine (General)
ISBN: 288919955X

Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.