Targeted Learning

Targeted Learning
Author: Mark J. van der Laan
Publisher: Springer Science & Business Media
Total Pages: 628
Release: 2011-06-17
Genre: Mathematics
ISBN: 1441997822

The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the target parameter representing the scientific question of interest. This book is aimed at both statisticians and applied researchers interested in causal inference and general effect estimation for observational and experimental data. Part I is an accessible introduction to super learning and the targeted maximum likelihood estimator, including related concepts necessary to understand and apply these methods. Parts II-IX handle complex data structures and topics applied researchers will immediately recognize from their own research, including time-to-event outcomes, direct and indirect effects, positivity violations, case-control studies, censored data, longitudinal data, and genomic studies.

Targeted

Targeted
Author: Brittany Kaiser
Publisher: HarperCollins
Total Pages: 435
Release: 2019-10-22
Genre: Political Science
ISBN: 0062965808

In this explosive memoir, a political consultant and technology whistleblower reveals the disturbing truth about the multi-billion-dollar data industry, revealing to the public how companies are getting richer using our personal information and exposing how Cambridge Analytica exploited weaknesses in privacy laws to help elect Donald Trump—and how this could easily happen again in the 2020 presidential election. When Brittany Kaiser joined Cambridge Analytica—the UK-based political consulting firm funded by conservative billionaire and Donald Trump patron Robert Mercer—she was an idealistic young professional working on her fourth degree in human rights law and international relations. A veteran of Barack Obama’s 2008 campaign, Kaiser’s goal was to utilize data for humanitarian purposes, most notably to prevent genocide and human rights abuses. But her experience inside Cambridge Analytica opened her eyes to the tremendous risks that this unregulated industry poses to privacy and democracy. Targeted is Kaiser’s eyewitness chronicle of the dramatic and disturbing story of the rise and fall of Cambridge Analytica. She reveals to the public how Facebook’s lax policies and lack of sufficient national laws allowed voters to be manipulated in both Britain and the United States, where personal data was weaponized to spread fake news and racist messaging during the Brexit vote and the 2016 election. But the damage isn’t done Kaiser warns; the 2020 election can be compromised as well if we continue to do nothing. In the aftermath of the U.S. election, as she became aware of the horrifying reality of what Cambridge Analytica had done in support of Donald Trump, Kaiser made the difficult choice to expose the truth. Risking her career, relationships, and personal safety, she told authorities about the data industry’s unethical business practices, eventually testifying before Parliament about the company’s Brexit efforts and helping Special Counsel Robert Mueller’s investigation into Russian interference in the 2016 election, alongside at least 10 other international investigations. Packed with never-before-publicly-told stories and insights, Targeted goes inside the secretive meetings with Trump campaign personnel and details the promises Cambridge Analytica made to win. Throughout, Kaiser makes the case for regulation, arguing that legal oversight of the data industry is not only justifiable but essential to ensuring the long-term safety of our democracy. Targeted includes 20-30 photos.

Targeted Cyber Attacks

Targeted Cyber Attacks
Author: Aditya Sood
Publisher: Syngress
Total Pages: 159
Release: 2014-04-18
Genre: Computers
ISBN: 0128006196

Cyber-crime increasingly impacts both the online and offline world, and targeted attacks play a significant role in disrupting services in both. Targeted attacks are those that are aimed at a particular individual, group, or type of site or service. Unlike worms and viruses that usually attack indiscriminately, targeted attacks involve intelligence-gathering and planning to a degree that drastically changes its profile. Individuals, corporations, and even governments are facing new threats from targeted attacks. Targeted Cyber Attacks examines real-world examples of directed attacks and provides insight into what techniques and resources are used to stage these attacks so that you can counter them more effectively. - A well-structured introduction into the world of targeted cyber-attacks - Includes analysis of real-world attacks - Written by cyber-security researchers and experts

Targeted

Targeted
Author: Stephen Hunter
Publisher: Simon and Schuster
Total Pages: 384
Release: 2022-01-18
Genre: Fiction
ISBN: 1982169796

"After being accused of reckless endangerment and forced to answer to the U.S. Congress, master sniper Bob Lee Swagger must protect political hostages in a once-in-a-lifetime standoff"--

Targeted Radionuclide Therapy

Targeted Radionuclide Therapy
Author: Tod W. Speer
Publisher: Lippincott Williams & Wilkins
Total Pages: 564
Release: 2012-03-28
Genre: Medical
ISBN: 1451153260

Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

A Beginner's Guide to Targeted Cancer Treatments

A Beginner's Guide to Targeted Cancer Treatments
Author: Elaine Vickers
Publisher: John Wiley & Sons
Total Pages: 359
Release: 2018-05-08
Genre: Medical
ISBN: 1119126835

Highly Commended in the category of Oncology at the British Medical Association Awards 2019 The accessible guide to the principles behind new, more targeted drug treatments for cancer Written for anyone who encounters cancer patients, cancer data or cancer terminology, but have no more than a passing knowledge of cell biology. A Beginner's Guide to Targeted Cancer Treatments provides an understanding of how cancer works and the many new treatments available. Using over 100 original illustrations, this accessible handbook covers the biology and mechanisms behind a huge range of targeted drug treatments, including many new immunotherapies. Dr Vickers translates a complex and often overwhelming topic into something digestible and easily understood. She also explains what cancer is, how it behaves and how our understanding of cancer has changed in recent years. Each chapter takes the reader through how new cancer drugs work and their benefits and limitations. With the help of this book, readers will be able to better understand more complex, in-depth articles in journals and books and develop their knowledge. This vital resource: Offers the latest insights into cancer biology Provides a broad understanding of how targeted cancer treatments work Describes many of the new immunotherapy approaches to cancer treatment, such as checkpoint inhibitors and CAR-modified T cells Helps readers feel confident discussing treatment options with colleagues and patients Provides an overview of which treatments are relevant to each of the most common solid tumours and haematological cancers, and the rationale behind them Demystifies the jargon – terms such as the EMT, cancer stem cells, monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors etc. Explains the resistance mechanisms to many new treatments, including issues such as the way cancer cells diversify and evolve and the complex environment in which they live

Targeted

Targeted
Author: Kendra Elliot
Publisher: Montlake Romance
Total Pages: 0
Release: 2016
Genre: Murder
ISBN: 9781503935044

On his quiet fishing trip, Detective Mason Callahan finds the body of his boss, Denny Schefte, near their remote Oregon cabin. The FBI assigns the case to Special Agent Ava McLane, Mason's fiancae, when they learn of the mask left at the scene. The FBI realizes that they are hunting a serial killer that targets police officers.

The Zero-Waste Chef

The Zero-Waste Chef
Author: Anne-Marie Bonneau
Publisher: Penguin
Total Pages: 0
Release: 2021-04-13
Genre: House & Home
ISBN: 0735239789

*SHORTLISTED for the 2021 Gourmand World Cookbook Award* *SHORTLISTED for the 2022 Taste Canada Award for Single-Subject Cookbooks* A sustainable lifestyle starts in the kitchen with these use-what-you-have, spend-less-money recipes and tips, from the friendly voice behind @ZeroWasteChef. In her decade of living with as little plastic, food waste, and stuff as possible, Anne-Marie Bonneau, who blogs under the moniker Zero-Waste Chef, has preached that "zero-waste" is above all an intention, not a hard-and-fast rule. Because, sure, one person eliminating all their waste is great, but thousands of people doing 20 percent better will have a much bigger impact. And you likely already have all the tools you need to begin. In her debut book, Bonneau gives readers the facts to motivate them to do better, the simple (and usually free) fixes to ease them into wasting less, and finally, the recipes and strategies to turn them into self-reliant, money-saving cooks and makers. Rescue a hunk of bread from being sent to the landfill by making Mexican Hot Chocolate Bread Pudding, or revive some sad greens to make a pesto. Save 10 dollars (and the plastic tub) at the supermarket with Yes Whey, You Can Make Ricotta Cheese, then use the cheese in a galette and the leftover whey to make sourdough tortillas. With 75 vegan and vegetarian recipes for cooking with scraps, creating fermented staples, and using up all your groceries before they go bad--including end-of-recipe notes on what to do with your ingredients next--Bonneau lays out an attainable vision for a zero-waste kitchen.

Targeted Protein Degradation

Targeted Protein Degradation
Author: Angela M. Cacace
Publisher: Humana
Total Pages: 351
Release: 2021-08-26
Genre: Science
ISBN: 9781071616642

This volume contains a collection of innovative techniques for studying targeted protein degradation. Chapters guide readers through heterobifunctional proteolysis-targeting chimeras (PROTACs) approaches, E3 ligase, E3 ligase-induced ubiquitylation, proteomic approaches, novel degrader molecules, molecular glue, and stabilize binding interaction between a target and E3 ubiquitin ligase. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Targeted Protein Degradation: Methods and Protocols aims to ensure successful results in this emerging field of drug discovery.