Regulation of Tissue Oxygenation, Second Edition

Regulation of Tissue Oxygenation, Second Edition
Author: Roland N. Pittman
Publisher: Biota Publishing
Total Pages: 117
Release: 2016-08-18
Genre: Medical
ISBN: 1615047212

This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

Regulation of Coronary Blood Flow

Regulation of Coronary Blood Flow
Author: Michitoshi Inoue
Publisher: Springer Science & Business Media
Total Pages: 330
Release: 2013-11-09
Genre: Medical
ISBN: 4431683674

Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.

Physical Examination of the Heart and Circulation

Physical Examination of the Heart and Circulation
Author: Joseph K. Perloff
Publisher: PMPH-USA
Total Pages: 292
Release: 2009
Genre: Cardiovascular system
ISBN: 9781607950233

Places emphasis on the physical examination. This title describes the physical signs and how they are elicited.

The Mechanics of the Circulation

The Mechanics of the Circulation
Author: C. G. Caro
Publisher: Cambridge University Press
Total Pages: 551
Release: 2012
Genre: Mathematics
ISBN: 0521151775

This classic book outlines the anatomy and physiology of the circulation and explains the mechanical principles that govern it.

Circulation of the Blood

Circulation of the Blood
Author: Alfred P. Fishman
Publisher: Springer
Total Pages: 871
Release: 2013-05-26
Genre: Medical
ISBN: 1461475465

Capturing the real spirit of creativity in physiology, this book explores the personal elements involved in scientific discovery. Circulation of the Blood is the story of the people and achievements that have changed the way we've come to view the human body. The authors, renowned for their extensive experience in the field, examine the heritage of creative genius involved in physiology and trace the historical development of ideas relating to various aspects of circulation of the blood. Their comprehensive coverage goes from the early discoveries of the Greeks and Romans up to modern times.

State of the Heart

State of the Heart
Author: Haider Warraich
Publisher: Macmillan + ORM
Total Pages: 213
Release: 2019-07-23
Genre: Medical
ISBN: 1250169712

In State of the Heart, Dr. Haider Warraich takes readers inside the ER, inside patients' rooms, and inside the history and science of cardiac disease. State of the Heart traces the entire arc of the heart, from the very first time it was depicted on stone tablets, to a future in which it may very well become redundant. While heart disease has been around for a while, the type of heart disease people have, why they have it, and how it’s treated is changing. Yet, the golden age of heart science is only just beginning. And with treatments of heart disease altering the very definitions of human life and death, there is no better time to look at the present and future of heart disease, the doctors and nurses who treat it, the patients and caregivers who live with it, and the stories they hold close to their chests. More people die of heart disease than any other disease in the world and when any form of heart disease progresses, it can result in the development of heart failure. Heart failure affects millions and can affect anyone at anytime, a child recovering from a viral infection, a woman who has just given birth or a cancer patient receiving chemotherapy. Yet new technology to treat heart failure is fundamentally changing just what it means to be human. Mechanical pumps can be surgically sown into patients’ hearts and when patients with these pumps get really sick, sometimes they don’t need a doctor or a surgeon—they need a mechanic. In State of the Heart, the journey to rid the world of heart disease is shown to be reflective of the journey of medical science at large. We are learning not only that women have as much heart disease as men, but that the type of heart disease women experience is diametrically different from that in men. We are learning that heart disease and cancer may have more in common than we could have imagined. And we are learning how human evolution itself may have led to the epidemic of heart disease. In understanding how our knowledge of the heart evolved, State of the Heart traces the twisting and turning road that science has taken—filled with potholes and blind turns—all the way back to its very origin.

Control of Cardiac Output

Control of Cardiac Output
Author: David Young
Publisher: Biota Publishing
Total Pages: 110
Release: 2010-01-01
Genre: Medical
ISBN: 1615040226

Although cardiac output is measured as the flow of blood from the left ventricle into the aorta, the system that controls cardiac output includes many other components besides the heart itself. The heart’s rate of output cannot exceed the rate of venous return to it, and therefore, the factors governing venous return are primarily responsible for control of output from the heart. Venous return is affected by its pressure gradient and resistance to flow throughout the vascular system. The pressure gradient for venous return is a function of several factors including the blood volume flowing through the system, the unstressed vascular volume of the circulatory system, its capacitance, mean systemic pressure, and right atrial pressure. Resistance to venous return is the sum of total vascular resistance from the aortic valve to the right atrium. The sympathetic nervous system and vasoactive circulating hormones affect short-term resistance, whereas local tissue blood flow autoregulatory mechanisms are the dominant determinants of long-term resistance to venous return. The strength of contraction of the heart responds to changes in atrial pressure driven by changes in venous return, with small changes in atrial pressure eliciting large changes in strength of contraction, as described by the Frank–Starling mechanism. In addition, the autonomic nervous system input to the heart alters myocardial pumping ability in response to cardiovascular challenges. The function of the cardiovascular system is strongly affected by the operation of the renal sodium excretion–body fluid volume–arterial pressure negative feedback system that maintains arterial blood pressure at a controlled value over long periods. The intent of this volume is to integrate the basic knowledge of these cardiovascular system components into an understanding of cardiac output regulation. Table of Contents: Introduction / Venous Return / Cardiac Function / Integrated Analysis of Cardiac Output Control / Analysis of Cardiac Output Regulation by Computer Simulation / Analysis of Cardiac Output Control in Response to Challenges / Conclusion / References / Author Biography

Hematology

Hematology
Author: Ronald Hoffman
Publisher:
Total Pages: 2821
Release: 2005
Genre: Blood
ISBN: 9780443066283