This Handbook provides the first comprehensive overview of sign language translation and interpretation from around the globe and looks ahead to future directions of research. Divided into eight parts, the book covers foundational skills, the working context of both the sign language translator and interpreter, their education, the sociological context, work settings, diverse service users, and a regional review of developments. The chapters are authored by a range of contributors, both deaf and hearing, from the Global North and South, diverse in ethnicity, language background, and academic discipline. Topics include the history of the profession, the provision of translation and interpreting in different domains and to different populations, the politics of provision, and the state of play of sign language translation and interpreting professions across the globe. Edited and authored by established and new voices in the field, this is the essential guide for advanced students and researchers of translation and interpretation studies and sign language.