Retroviruses

by John M. Coffin
Retroviruses
Author: John M. Coffin
Publisher: CSHL Press
Total Pages: 856
Release: 1997
Genre: Electronic books
ISBN: 9780879695712
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For over 25 years the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biochemical mechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphoma have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This remarkable volume satisfies that need. Written by a group of the field's most distinguished investigators, rigorously edited to provide a seamless narrative, and elegantly designed for clarity and readability, this book is an instant classic that demands attention from scientists and physicians studying retroviruses and the disorders in which they play a role.

Human Retroviruses

by Bryan Cullen
Human Retroviruses
Author: Bryan Cullen
Publisher: Oxford University Press
Total Pages: 220
Release: 1993
Genre: Gene Expression Regulation.
ISBN: 9780199633821
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The first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.

Discovering Retroviruses

by Anna Marie Skalka
Discovering Retroviruses
Author: Anna Marie Skalka
Publisher: Harvard University Press
Total Pages: 193
Release: 2018-10-15
Genre: Science
ISBN: 0674988752
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Approximately eight percent of our DNA contains retroviral sequences that are millions of years old. Through engaging stories of scientific discovery, Anna Marie Skalka explains our evolving knowledge of these ancient denizens of the biosphere and how this understanding has significantly advanced research in genetic engineering, gene delivery systems, and precision medicine. Discovering Retroviruses begins with the pioneer scientists who first encountered these RNA-containing viruses and solved the mystery of their reproduction. Like other viruses, retroviruses invade the cells of a host organism to reproduce. What makes them “retro” is a unique process of genetic information transfer. Instead of transcribing DNA into RNA as all living cells do, they transcribe their RNA into DNA. This viral DNA is then spliced into the host’s genome, where the cell’s synthetic machinery is co-opted to make new virus particles. The 100,000 pieces of retroviral DNA in the human genome are remnants from multiple invasions of our ancestors’ “germline” cells—the cells that allow a host organism to reproduce. Most of these bits of retroviral DNA are degenerated fossils, but some have been exploited during evolution, with profound effects on our physiology. Some present-day circulating retroviruses cause cancers in humans and other animals. Others, like HIV, cause severe immunodeficiencies. But retroviruses also hold clues to innovative approaches that can prevent and treat these diseases. In laboratories around the world, retroviruses continue to shed light on future possibilities that are anything but “retro.”

Retroviruses

by Reinhard Kurth
Retroviruses
Author: Reinhard Kurth
Publisher: Caister Academic Press Limited
Total Pages: 0
Release: 2010
Genre: Science
ISBN: 9781904455554
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Leading scientists in the field review the genomics, molecular biology and pathogenesis of these important viruses, comprehensively covering all the recent advances.

The Retroviridae

by Jay A. Levy
The Retroviridae
Author: Jay A. Levy
Publisher: Springer Science & Business Media
Total Pages: 455
Release: 2013-06-29
Genre: Medical
ISBN: 148991627X
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In this second volume in the series The Retroviridae, the readers are treated to up-to-date reviews on these viruses, which are found in a variety of animal species. The volume begins with important observations on the general fea tures of retrovirus entry into cells as determined by the viral envelope glyco proteins and the cell surface receptors (Chapter 1). Aspects of this virus-cell interaction form the basis for the variety of biologic effects associated with this virus family. A timely review of the oncogenic feline viruses is included next (Chapter 2). These viruses, along with the avian and murine retroviruses (Volume 1, Chapters 6 and 7), have provided valuable insight into cancer induction in other animal species, including humans. Two other major groups of retroviruses, the lentiviruses and the spuma viruses, are introduced in the present volume. Initially these groups, along with oncoviruses, were the three subfamilies in the Retroviridae. This com plex virus family has now been reclassified into seven separate genera (Vol ume 1, Chapter 2). Equine infectious anemia virus is the prototype for a lentivirus (Chapter 5). One of the first viruses discovered in nature (1904), it was only relatively recently recognized as a retrovirus. Lentiviruses are asso ciated primarily with immunologic disorders such as autoimmunity and AIDS (Chapters 3-5), but their association with neurologic disease is also well established (Chapters 4 and 5, and future volumes).

Jaagsiekte Sheep Retrovirus and Lung Cancer

by Hung Y. Fan
Jaagsiekte Sheep Retrovirus and Lung Cancer
Author: Hung Y. Fan
Publisher: Springer Science & Business Media
Total Pages: 255
Release: 2012-12-06
Genre: Medical
ISBN: 3642556388
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Retroviruses have been of great importance to biomedical science for the past half century. Initially, studies on oncogenic animal retroviruses provided important insights into molecular processes in carcinogenesis – most notably the existence and mechanisms of action of oncogenes and proto-oncogenes. Moreover, several human diseases are caused by retroviruses, including AIDS, adult T-cell leukemia and the neurological disease HAM/TSP. The topic of this volume is a relatively unknown animal retrovirus, jaagsiekte sheep retrovirus, the causative agent of transmissible lung cancer in sheep –ovine pulmonary adenocarcinoma. The disease was first documented in South Africa in the 1800s, it has a wide geographical distribution, and it is of economic importance in high endemic regions. However, until very recently the nature of the etiologic agent was unclear, and relatively few laboratories actively studied the disease.

Neurotropic Viral Infections

by Carol Shoshkes Reiss
Neurotropic Viral Infections
Author: Carol Shoshkes Reiss
Publisher: Springer
Total Pages: 562
Release: 2016-09-08
Genre: Medical
ISBN: 3319331892
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This second edition is a comprehensive study of the viruses that affect the brain and the central nervous system. Along with a focus on the viruses themselves, it addresses the diseases they cause, current treatments and preventive measures. Also discussed are the unique aspects of how viruses cause disease and why certain hosts are more susceptible (e.g., polymorphisms, age, co-morbidities). Because there are 29 cutting edge chapters, written by experts in the fields, Neurotropic Viral Infections has been divided into two separate volumes. Volume 1, Neurotropic RNA Viruses, includes 14 chapters on RNA viruses that cause human disease of the central nervous system ranging from Bornavirus to polio to West Nile. Volume 2, Neurotropic Retroviruses, DNA Viruses, Immunity and Transmission, includes 15 chapters divided into two parts. Part 1 includes 7 chapters on retroviruses and DNA viruses that cause human disease of the central nervous system ranging from HIV to varicella zoster virus. Part 2 includes chapters on transmission of these viruses by transplantation, bites by bats and insects, clinical management of the infections, and beneficial uses of attenuated viruses. Neurotropic Viral Infections is a unique resource, bridging basic, clinical, and translational approaches.​

Diseases of Swine

by Jeffrey J. Zimmerman
Diseases of Swine
Author: Jeffrey J. Zimmerman
Publisher: John Wiley & Sons
Total Pages: 1136
Release: 2019-06-18
Genre: Medical
ISBN: 1119350859
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Provides a fully revised Eleventh Edition of the definitive reference to swine health and disease Diseases of Swine has been the definitive reference on swine health and disease for over 60 years. This new edition has been completely revised to include the latest information, developments, and research in the field. Now with full color images throughout, this comprehensive and authoritative resource has been redesigned for improved consistency and readability, with a reorganized format for more intuitive access to information. Diseases of Swine covers a wide range of essential topics on swine production, health, and management, with contributions from more than 100 of the foremost international experts in the field. This revised edition makes the information easy to find and includes expanded information on welfare and behavior. A key reference for anyone involved in the swine industry, Diseases of Swine, Eleventh Edition: Presents a thorough revision to the gold-standard reference on pig health and disease Features full color images throughout the book Includes information on the most current advances in the field Provides comprehensive information on swine welfare and behavior Offers a reorganized format to make the information more accessible Written for veterinarians, academicians, students, and individuals and agencies responsible for swine health and public health, Diseases of Swine, Eleventh Edition is an essential guide to swine health. "The 11th edition of Diseases of Swine continues to serve as the gold-standard resource for anything and everything related to swine herd health...this edition does an outstanding job of keeping up with the advanced diagnostic technologies and the latest research on new or emerging diseases and syndromes...there is no other informational resource that comes close to providing the depth or quality of information on the topic of swine diseases as does this book"

Plague

by Kent Heckenlively
Plague
Author: Kent Heckenlively
Publisher: Simon and Schuster
Total Pages: 604
Release: 2017-02-21
Genre: Science
ISBN: 1510726357
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On July 22, 2009, a special meeting was held with twenty-four leading scientists at the National Institutes of Health to discuss early findings that a newly discovered retrovirus was linked to chronic fatigue syndrome (CFS), prostate cancer, lymphoma, and eventually neurodevelopmental disorders in children. When Dr. Judy Mikovits finished her presentation the room was silent for a moment, then one of the scientists said, “Oh my God!” The resulting investigation would be like no other in science. For Dr. Mikovits, a twenty-year veteran of the National Cancer Institute, this was the midpoint of a five-year journey that would start with the founding of the Whittemore-Peterson Institute for Neuro-Immune Disease at the University of Nevada, Reno, and end with her as a witness for the federal government against her former employer, Harvey Whittemore, for illegal campaign contributions to Senate Majority Leader Harry Reid. On this journey Dr. Mikovits would face the scientific prejudices against CFS, wander into the minefield that is autism, and through it all struggle to maintain her faith in God and the profession to which she had dedicated her life. This is a story for anybody interested in the peril and promise of science at the very highest levels in our country.