This handbook compiles the most up-to-date research on transnational families. It employs a dialogue between classical approaches and cutting-edge directions in transnational family research to identify continuities and changes in terms of socioeconomic disparities and actors, and to analyze coexistence. Further, the volume adopts a twofold global and international comparative perspective. On the one hand, it focuses on different migratory flows around the world and describes their entangled logics; on the other, it is written by an international group of contributors, with a diverse range of professional backgrounds. Their contributions are based on sound empirical research, and explore geographical regions around the world. The handbook presents different thematic perspectives on transnational families, including an analytical focus on gender, global sociodemographic inequalities, power asymmetries, and border- and mobility regimes, as well as the organization of transnational care, transnational fatherhood, ageing, family reunions and return. It also includes a variety of methodological approaches to transnational family research, ranging from ethnography, biographical research, and life-course methods, to multi-sited approaches and quantitative surveys. Investigating an emergent debate, it sheds new light on migratory fluxes, their common and specific determinants, the types of actors involved, and ways to empirically and methodologically approach them. This is a must-read reference for social scientists interested in family research, migration, and gender studies. Chapter 7 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.