| Author | : A. Douglas Kinghorn |
| Publisher | : Springer Nature |
| Total Pages | : 274 |
| Release | : 2019-10-16 |
| Genre | : Science |
| ISBN | : 3030146324 |
The book summarizes important aspects of cheminformatics that are relevant for natural product research. It highlights cheminformatics tools that help to match natural products with their respective biological targets or off-targets, and discusses the potential and limitations of this approach.
| Author | : |
| Publisher | : Springer |
| Total Pages | : 317 |
| Release | : 2011-10-01 |
| Genre | : Science |
| ISBN | : 9783709174562 |
The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer imprint ever since the series was founded in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
| Author | : H. Budzikiewicz |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 273 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 3709105811 |
| Author | : A Douglas Kinghorn |
| Publisher | : Springer Nature |
| Total Pages | : 247 |
| Release | : 2021-04-16 |
| Genre | : Science |
| ISBN | : 3030530280 |
In this book, chemical studies are described mainly from literature reports appearing since 2000, inclusive of investigations performed by the present authors, on the diversity in secondary metabolites of Ligularia growing in the Hengduan Mountains area of China, focusing on eremophilane sesquiterpenoids and other metabolites. More than 100 Ligularia species and their related genera in the plant family Senecioneae plants (Cremanthodium, Cacalia, Senecio, and others) grow in East Asia. For many years, researchers have studied the chemical constituents of these plants, and terpenoids, flavonoids, steroids, alkaloids, and aromatic compounds have been isolated. Among these, in particular, numerous sesquiterpenoids were reported. Within this book terpenoids and aromatic compounds (total 1049), both previously unknown and known, are presented. Finally, genetic studies and synthesis investigations are briefly reviewed.
| Author | : A. Douglas Kinghorn |
| Publisher | : Springer Nature |
| Total Pages | : 341 |
| Release | : 2021-04-01 |
| Genre | : Science |
| ISBN | : 3030594440 |
This book describes current understandings and recent progress in four areas: in the first one, the cytochalasans, a group of fungal derived natural products characterized by a perhydro-isoindolone core fused with a macrocyclic ring are shown to exhibit high structural diversity and a broad spectrum of bioactivities. The second one is dedicated to a description of bioactive compounds from the medicinal plants of Myanmar, the third one is dedicated to new structure elucidation techniques in the field of sesquiterpenes. The last one discusses the endogenous natural products that are produced by human cells including endogenous amines, steroids, and fatty acid derived natural products. The co-metabolism and natural product production of the human microbiome is also described including tryptophan, bile acids, choline, and cysteine.
| Author | : A. Douglas Kinghorn |
| Publisher | : Springer Nature |
| Total Pages | : 265 |
| Release | : 2021-10-26 |
| Genre | : Science |
| ISBN | : 3030805603 |
This volume describes several highly diverse subjects: Chapter 1 explores marine biodiscovery of the North-eastern Atlantic off the coast of Ireland as a model for best practice in research. The second chapter investigates Brazilian Chemical Ecology and examples of insect-plant communication studies that are mediated by natural products demonstrate the beautiful interconnectedness of species in a biome. Our third chapter comprises the advances in the science of the sesquiterpene quinone, perezone, which in 1852 was the first natural product isolated in crystalline form in the New World. The last two chapters are from a Vietnamese group and the first of these follows the phytochemistry, pharmacology, and ethnomedical uses of the genus Xanthium, which produces interesting sulfur and nitrogen containing natural products. Finally, the genus Desmos is discussed, where an overview of its constituent natural products and their in vitro pharmacological potential is described.
| Author | : A. Douglas Kinghorn |
| Publisher | : Springer Nature |
| Total Pages | : 239 |
| Release | : |
| Genre | : |
| ISBN | : 303159567X |
| Author | : A. Douglas Kinghorn |
| Publisher | : Springer Nature |
| Total Pages | : 183 |
| Release | : 2022-04-13 |
| Genre | : Science |
| ISBN | : 3030920305 |
This volume consists of four chapters that cover a structurally diverse range of naturally occurring compounds. Chapter 1 delves into the chemistry of pyrogallols and their oxidized products, the hydroxy-o-quinones, including their role in cycloaddition reactions in the chemical synthesis of several fungal metabolites. Chapter 2 provides an in-depth description of the constituents of agarwood essential oil and smoke samples that are used in the perfumery industry, with an emphasis on the sesquiterpenoid and chromones constituents so far known. Chapter 3 discusses the defensive chemical ecology of two North American newt species that both produce tetrodotoxin, a well-known neurotoxin that causes paralysis and death in metazoans by disrupting electrical signals in the nerves and muscles. Chapter 4 discusses the limonoids and triterpenoids from the genus Walsura of the plant family Meliaceae, of which a number of species are utilized in several southeastern Asian countries in systems of folk medicine.
| Author | : A. Douglas Kinghorn |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 269 |
| Release | : 2011-08-12 |
| Genre | : Science |
| ISBN | : 3709107482 |
The three reviews cover the advances in the chemistry and biology of withanolides over the last 16 years, review the chemistry and biology of the rocaglamide-type derivatives and related compounds, with emphasis on their structural diversity, biosynthesis, pharmacological significance and total synthesis, and summarize the extensive chemistry and biology studies on a natural product, which have resulted in a novel therapy approved worldwide.
